Neopra 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (30's pack: ৳ 150.00)

Medicine Details

Category Details
Generic Omeprazole
Company Supreme pharmaceutical ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • Treatment of NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Treatment of Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in gastric parietal cell
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Return of secretory activity after discontinuation occurs over 3 to 5 days

Dosage

  • Dosage varies based on the condition being treated
  • Oral and IV administration
  • Different doses for different conditions such as ulcers, reflux disease, and Zollinger-Ellison syndrome
  • Specific dosage for Helicobacter pylori eradication regimen

Administration

  • IV injection administration
  • IV infusion administration
  • Specific instructions for reconstitution and intravenous administration
  • Caution on mixing with other drugs in the same infusion set

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin recommended
  • Increase in plasma concentrations during concomitant administration with clarithromycin

Contraindications

  • Contraindicated in patients with known hypersensitivity to omeprazole
  • Possibility of malignancy in suspected gastric ulcer should be excluded before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme in isolated cases
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light headedness, and feeling faint
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms

Pregnancy & Lactation

  • No adverse effects on pregnancy or health of fetus/newborn child reported from studies
  • No information available on passage into breast milk or effects on neonate

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possibly associated with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treatment
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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