O-40 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (20's pack: ৳ 140.00)

Medicine Details

Category Details
Generic Omeprazole
Company Asiatic laboratories ltd
Also available as
O 20 20 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis for patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Substituted benzimidazole
  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Oral dosage for various conditions
  • IV Injection dosage for prophylaxis of acid aspiration
  • IV Injection dosage for duodenal ulcer, gastric ulcer, or reflux esophagitis
  • IV Injection dosage for Zollinger-Ellison syndrome
  • Paediatric use dosage in severe ulcerating reflux esophagitis
  • Helicobacter pylori eradication regimen in peptic ulcer disease dosage

Administration

  • IV Injection instructions
  • IV Infusion instructions
  • Reconstitution and administration guidelines
  • Instructions for intravenous administration
  • Preparation and usage guidance

Interaction

  • Decreased intragastric acidity affecting ketoconazole absorption
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Monitoring and potential dose adjustment of warfarin or phenytoin
  • Plasma concentrations during concomitant administration
  • Absence of interaction with certain drugs
  • Interaction with digoxin leading to increased bioavailability

Contraindications

  • Patients with known hypersensitivity to omeprazole
  • Consideration of malignancy before treatment
  • Possible delay in diagnosis

Side Effects

  • Mild and reversible adverse reactions
  • Reported skin rash, urticaria, and pruritus
  • Adverse gastrointestinal reactions
  • Isolated cases of neurological and psychiatric symptoms
  • Reversible mental confusion, agitation, and depression
  • Reported cases of liver enzyme increases

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child observed in epidemiological studies
  • Usage during pregnancy
  • No information on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential use is considered
  • Safety and effectiveness not established in pediatric patients

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Increased risk for osteoporosis-related fractures
  • Occasional occurrence of atrophic gastritis
  • Potential for methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton pump inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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