O-40 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.00 (20's pack: ৳ 140.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Asiatic laboratories ltd |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer treatment
- Prophylaxis for patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease treatment
- Long-term management of acid reflux disease
- Treatment of acid-related dyspepsia
- Severe ulcerating reflux esophagitis treatment
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome treatment
- Helicobacter pylori-induced peptic ulcer treatment
Pharmacology
- Substituted benzimidazole
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- Oral dosage for various conditions
- IV Injection dosage for prophylaxis of acid aspiration
- IV Injection dosage for duodenal ulcer, gastric ulcer, or reflux esophagitis
- IV Injection dosage for Zollinger-Ellison syndrome
- Paediatric use dosage in severe ulcerating reflux esophagitis
- Helicobacter pylori eradication regimen in peptic ulcer disease dosage
Administration
- IV Injection instructions
- IV Infusion instructions
- Reconstitution and administration guidelines
- Instructions for intravenous administration
- Preparation and usage guidance
Interaction
- Decreased intragastric acidity affecting ketoconazole absorption
- Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
- Monitoring and potential dose adjustment of warfarin or phenytoin
- Plasma concentrations during concomitant administration
- Absence of interaction with certain drugs
- Interaction with digoxin leading to increased bioavailability
Contraindications
- Patients with known hypersensitivity to omeprazole
- Consideration of malignancy before treatment
- Possible delay in diagnosis
Side Effects
- Mild and reversible adverse reactions
- Reported skin rash, urticaria, and pruritus
- Adverse gastrointestinal reactions
- Isolated cases of neurological and psychiatric symptoms
- Reversible mental confusion, agitation, and depression
- Reported cases of liver enzyme increases
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child observed in epidemiological studies
- Usage during pregnancy
- No information on passage into breast milk or effects on neonate
- Discontinuation of breastfeeding if essential use is considered
- Safety and effectiveness not established in pediatric patients
Precautions & Warnings
- Avoid concomitant use of clopidogrel and omeprazole
- Increased risk for osteoporosis-related fractures
- Occasional occurrence of atrophic gastritis
- Potential for methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
- Proton pump inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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