OC-20 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)

Medicine Details

Category Details
Generic Omeprazole
Company Central pharmaceuticals ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia treatment
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Different dosages for various indications and patient populations
  • Oral administration for benign gastric and duodenal ulcer, NSAID-associated duodenal or gastric ulcer, gastro-esophageal reflux disease, long-term management of acid reflux disease, acid-related dyspepsia, Zollinger-Ellison syndrome, Helicobacter pylori eradication regimen, and pediatric use in severe ulcerating reflux esophagitis
  • Intravenous administration for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer, reflux esophagitis, and Zollinger-Ellison syndrome

Administration

  • Directions for intravenous injection
  • Directions for intravenous infusion
  • Instructions for reconstitution and usage

Interaction

  • Potential impact on the absorption of other medications
  • Metabolism through cytochrome P450
  • Potential interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, amoxicillin, metronidazole, digoxin, and more

Contraindications

  • Known hypersensitivity to omeprazole
  • Caution in patients with suspected gastric ulcer to exclude the possibility of malignancy

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, pruritus, photosensitivity, bullous eruption, and more
  • Gastrointestinal reactions like diarrhea, nausea/vomiting, flatulence, abdominal pain
  • Neurological reactions like dizziness, headache, somnolence, insomnia, vertigo, and more
  • Hematological and hepatic reactions

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • Use during pregnancy
  • Lack of information on passage into breast milk and effects on the neonate
  • Discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in patients treated long-term
  • Potential for methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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