Urinide 5 mg (Tablet)

Unit Price: ৳ 18.00 (2 x 10: ৳ 360.00)
Strip Price: ৳ 180.00

Medicine Details

Category Details
Generic Bumetanide
Company Navana pharmaceuticals ltd
Also available as
Urinide 1 mg tablet

Indications

  • Treatment of edema associated with congestive heart failure
  • Treatment of edema associated with hepatic disease
  • Treatment of edema associated with renal disease
  • Treatment of edema associated with the nephrotic syndrome

Pharmacology

  • Rapid onset and short duration of action
  • Equivalent diuretic potency of 1 mg Bumetanide to approximately 40 mg furosemide
  • Major site of action is the ascending limb of the loop of Henle
  • Inhibition of sodium and chloride reabsorption in the ascending limb of the loop of Henle
  • Possible additional action in the proximal tubule
  • No noticeable action on the distal tubule

Dosage & Administration

  • Oral dosage: 1 mg in the morning, repeated after 6-8 hours if necessary
  • Severe cases may require 5 mg daily increased by 5 mg every 12-24 hours
  • Dosage for IV injection and infusion
  • Dosage for IM injection
  • Special precautions for pediatric use

Interaction

  • Interaction with lithium
  • Interaction with probenecid
  • Interaction with indomethacin
  • Potentiation of antihypertensive drugs
  • No effect on digoxin blood levels
  • No effect on warfarin metabolism

Contraindications

  • Avoid in severe hypokalaemia
  • Avoid in severe hyponatraemia
  • Avoid in anuria
  • Avoid in comatose and precomatose states associated with liver cirrhosis
  • Avoid in renal failure

Side Effects

  • Muscle cramps
  • Dizziness
  • Hypotension
  • Headache
  • Nausea
  • ECG changes
  • Musculoskeletal pain
  • Abdominal pain
  • Renal failure
  • Thrombocytopenia

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate and well-controlled studies in pregnant women
  • Unknown excretion in human milk

Precautions & Warnings

  • Periodic measurement of serum potassium
  • Need for potassium supplements or potassium-sparing diuretics

Use in Special Populations

  • Safety and effectiveness in pediatric patients below the age of 18 not established

Overdose Effects

  • Acute profound water loss
  • Volume and electrolyte depletion
  • Dehydration
  • Reduction of blood volume
  • Circulatory collapse
  • Vascular thrombosis and embolism
  • Treatment consists of replacement of fluid and electrolyte losses

Therapeutic Class

  • Loop diuretics

Storage Conditions

  • Temperature below 30°C
  • Away from light & moisture
  • Keep out of the reach of children

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