OM 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 3.02 (40's pack: ৳ 120.80)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Ambee pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral administration for various conditions and durations
- Initial doses for different ulcer types
- Maintenance doses for recurrent conditions
- Specific regimens for peptic ulcer disease and pediatric use
- IV injection for prophylaxis and specific syndromes
- Initial and recommended doses for Zollinger-Ellison Syndrome
Administration
- Specific directions for IV injection and IV infusion
- Reconstitution guidelines for IV injection and infusion
- Usage duration of reconstituted solution
- Precautions on mixing or co-administering with other drugs
Interaction
- Effects on absorption of ketoconazole and other drugs during treatment
- Metabolism in the liver through cytochrome P450
- Potential delay in elimination of diazepam, phenytoin, and warfarin
- Monitoring and dosage adjustments for patients receiving warfarin or phenytoin
- Plasma concentration changes during concomitant administration
- No evidence of interaction with certain drugs
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy before treatment
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme reported in isolated cases
- Diarrhoea, headache, constipation, nausea/vomiting, and abdominal pain
- Dry mouth, stomatitis, candidiasis, and paraesthesia reported
- Dizziness, light headedness, and feeling faint associated with treatment
- Resolvable mental confusion, agitation, depression, and hallucinations in severely ill patients
- Arthritic and myalgic symptoms reported and resolved upon therapy cessation
- Various isolated cases including blurred vision, taste disturbance, and gynaecomastia
Pregnancy & Lactation
- No adverse effects on pregnancy or health of fetus/newborn child from prospective studies
- Safe use during pregnancy
- No available information on passage into breast milk or effects on the neonate
- Breast-feeding discontinuation if essential use is considered
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use of clopidogrel and omeprazole
- Increased risk of osteoporosis-related fractures with proton pump inhibitor therapy
- Atrophic gastritis occurrence with long-term treatment
- Potential methotrexate toxicities with co-administration of PPIs
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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