OM 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 6.00 (20's pack: ৳ 120.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Ambee pharmaceuticals ltd |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer treatment
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease treatment
- Long-term management of acid reflux disease
- Acid-related dyspepsia treatment
- Severe ulcerating reflux esophagitis treatment
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome treatment
- Helicobacter pylori-induced peptic ulcer treatment
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg daily for severe or recurrent cases of gastric and duodenal ulcer
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for acid-related dyspepsia
- 40 mg on preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
- Initially 60 mg once daily for Zollinger-Ellison syndrome
- 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
- 10-40 mg once daily for severe ulcerating reflux esophagitis (paediatric use)
Administration
- IV Injection for prophylaxis of acid aspiration, duodenal and gastric ulcer, and reflux oesophagitis
- IV Infusion for severe ulcerating reflux esophagitis
- Reconstitution and usage guidelines for IV injection and infusion
Interaction
- Potential interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, and digoxin
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity and bullous eruption
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, and light headedness
- Reversible mental confusion, agitation, and depression
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, and peripheral oedema
- Increased sweating, gynaecomastia, and leucopenia
- Hepatitis, interstitial nephritis, and hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or on the health of the fetus/newborn child
- Safe for use during pregnancy
- No information available on passage into breast milk or effects on neonate
- Discontinuation of breastfeeding if essential use of omeprazole
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Increased risk for osteoporosis-related fractures
- Occasional atrophic gastritis in long-term use
- Possible methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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