Foly 15 mg (Tablet)
Unit Price: ৳ 25.00 (2 x 14: ৳ 700.00)
Strip Price: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Drug international ltd |
| Also available as |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists
- The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy
- infancy, liver disease and malabsorption syndrome
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Calcium Folinate Hydrate is the calcium salt of folinic acid, a metabolite and active form of folic acid
- Involved as a cofactor for 1-carbon transfer reactions in the biosynthesis of purine and pyrimidines of nucleic acids
Dosage & Administration
- Dose of methotrexate varies, folinate rescue treatment commence approximately 24 hours after methotrexate infusion
- Dosage regimens vary depending upon the dose of methotrexate administered
- Recommended dose to counteract hematologic toxicity from folic acid antagonists with less affinity for mammalian dihydrofolate reductase than methotrexate is 5-15 mg per day
Interaction
- Folinates may counteract the antiepileptic effect of phenobarbitone, phenytoin and primidone
- Caution required during concurrent administration of calcium folinate with fluoropyrimidine
Contraindications
- Hypersensitivity to calcium folinate or any other components
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Use in pregnant women only if potential benefit justifies potential risk to the fetus
- Caution should be exercised when calcium folinate is administered to a nursing mother
Precautions & Warnings
- Use only with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- In general, calcium folinate should not be given simultaneously with folic acid antagonists, e.g. methotrexate, to abort clinical toxicity as the therapeutic effect of the antagonist may be nullified
Overdose Effects
- No reported sequelae in patients who received more calcium folinate than recommended dosage
- Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
Therapeutic Class
- Supportive Care Therapy
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children