OME 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Somatec pharmaceuticals ltd |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer treatment
- As prophylaxis for patients with history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease treatment
- Long-term management of acid reflux disease
- Treatment of acid-related dyspepsia
- Severe ulcerating reflux esophagitis treatment
- Prophylaxis of acid aspiration during general anesthesia
- Treatment of Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer treatment
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer (4 weeks in duodenal ulceration, 8 weeks in gastric ulceration)
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer
- 40 mg once daily for severe or recurrent cases of duodenal and gastric ulcer
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for acid-related dyspepsia (2-4 weeks)
- 40 mg for prophylaxis of acid aspiration before surgery
Administration
- Direction for use of IV injection
- Direction for use of IV infusion
Interaction
- Decreased intragastric acidity affecting ketoconazole absorption
- Metabolized in the liver through cytochrome P450
- Delay in elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin recommended
- Plasma concentrations increase during concomitant administration with clarithromycin
Contraindications
- Known hypersensitivity
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhea and headache
- Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
- No information available on the passage of Omeprazole into breast milk
Precautions & Warnings
- Avoid concomitant use of clopidogrel
- Potential association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in gastric corpus biopsies from patients treated long-term with Omeprazole
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
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