Omelet 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.02 (30's pack: ৳ 210.60)

Medicine Details

Category Details
Generic Omeprazole
Company Amulet pharmaceuticals ltd
Also available as
Omelet 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily in severe or recurrent cases
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-20 mg once daily for paeditaric use in severe ulcerating reflux esophagitis

Administration

  • IV injection for prophylaxis of acid aspiration
  • IV infusion over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity may reduce absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations increased during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, and more

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer, excluding malignancy before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Diarrhoea and headache
  • Constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light headedness, and feeling faint
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Observational studies suggest PPI therapy may be associated with an increased risk for osteoporosis-related fractures

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat

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