Carvetab 6.25 mg (Tablet)
Unit Price: ৳ 3.00 (50's pack: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate, or severe heart failure of ischemic or cardiomyopathic origin
- Reduction of disease progression
- Combination therapy with digitalis, diuretics, and ACE inhibitor
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of beta-adrenergic receptors
- Alpha-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Treatment of hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Initial dose of 12.5 mg twice daily for angina pectoris
- Initial dose of 3.125 mg twice daily for heart failure
- Maximum dose of 50 mg daily for hypertension in elderly patients
- Maximum daily dose of 50 mg for elderly patients with angina pectoris
- Maximum dose of 50 mg twice daily for patients over 85 kg with heart failure
Interaction
- Increased levels of digoxin when taken together with Carvetab
- Monitoring of digoxin when initiating, adjusting, or discontinuing Carvetab
- 60% decrease in Cmax and AUC with rifampin pretreatment
- No alteration in the in vitro plasma protein binding of warfarin
- Potentiation of the pressor reaction with clonidine withdrawal
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock
- Severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral oedema
- Dry mouth
- Impotence
- Influenza-like symptoms
- Angina
- Exacerbation of intermittent claudication
- Allergic skin reactions
- Exacerbation of psoriasis
- Nasal stuffiness
- Wheezing
- Depressed mood
- Changes in liver enzymes
- Thrombocytopenia
- Leukopenia
Pregnancy & Lactation
- Not recommended during breastfeeding
- Excretion in breast milk
- No established safety and efficacy in children
- Crosses the placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitoring of clinical status after initiation and dose increases
- Assessment of renal function and heart failure
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children