Omeprol 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (6 x 10: ৳ 300.00)
Strip Price: ৳ 50.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Ziska pharmaceuticals ltd |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer treatment
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease treatment
- Long-term management of acid reflux disease
- Management of acid-related dyspepsia
- Severe ulcerating reflux esophagitis treatment
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome treatment
- Helicobacter pylori-induced peptic ulcer treatment
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of the antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasting up to 72 hours
- Gradual return of secretory activity over 3 to 5 days
Dosage
- Benign gastric and duodenal ulcer dosage
- NSAID-associated duodenal or gastric ulcer dosage
- Gastro-esophageal reflux disease dosage
- Long-term management of acid reflux disease dosage
- Acid-related dyspepsia dosage
- Prophylaxis of acid aspiration dosage
- Zollinger-Ellison syndrome dosage
- Helicobacter pylori eradication regimen
- Paediatric use in severe ulcerating reflux esophagitis dosage
- IV Injection dosage
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Slow intravenous injection
- Intravenous infusion over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism in the liver through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
- Monitoring of patients receiving warfarin or phenytoin
- Plasma concentrations of Omeprol and clarithromycin during concomitant administration
- Phenytoin blood concentration during continuous treatment
- Coagulation time in patients on continuous treatment with warfarin
- No evidence of interaction with various medications and antacids
Contraindications
- Known hypersensitivity to Omeprazole
- Suspicion of malignancy in gastric ulcer
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Gastrointestinal reactions including constipation, nausea/vomiting, and abdominal pain
- Diarrhoea and headache
- Dizziness, light-headedness, and feeling faint
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Increases in liver enzymes
Pregnancy & Lactation
- Results from prospective epidemiological studies
- No adverse effects on pregnancy or on the health of the fetus/newborn child
- No information available on the passage of Omeprazole into breast milk or its effects on the neonate
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Omeprazole
- Increased risk for osteoporosis-related fractures
- Occasional atrophic gastritis in gastric corpus biopsies from long-term treatment
- Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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