Omeprol 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.00 (5 x 8: ৳ 280.00)
Strip Price: ৳ 56.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Ziska pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
Inhibitor of gastric acid secretion, blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system, onset of antisecretory effect occurs within one hour, maximum effect within two hours, inhibition of secretion lasts up to 72 hours
Dosage
- 20 mg once daily for 4 weeks in duodenal ulceration
- 40 mg once daily in severe or recurrent cases
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for 4-8 weeks in Gastro-esophageal reflux disease
- Maintenance dose of 20 mg once daily
- 10-20 mg daily for long-term management of acid reflux disease
- 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
- Recommended dose of 20 mg twice daily in Helicobacter pylori eradication regimen
Administration
- IV Injection given slowly over a period of 5 minutes
- IV Infusion over a period of 20-30 minutes or more
- Solution for IV infusion should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose
Interaction
- Decreased intragastric acidity may reduce the absorption of ketoconazole
- Metabolised in the liver through cytochrome P450, can delay the elimination of various drugs
- Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
Contraindications
Contraindicated in patients with known hypersensitivity to it
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Dizziness, light-headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Thrombocytopenia, anaphylactic shock, malaise, fever, bronchospasm, and hepatic failure
Pregnancy & Lactation
Results from three prospective epidemiological studies indicate no adverse effects on pregnancy or on the health of the fetus/newborn child. Use in children & adolescents under 18 years not established
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Observational studies suggest an increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in long-term treatment
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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