Polyxim 100 mg/5 ml (Powder for Suspension)

Indications

• Upper Respiratory Tract Infections (URTI)
• Lower Respiratory Tract Infections
• Urinary Tract Infections
• Clinical Efficacy Against Specific Pathogens
• Stability in Presence of Beta-lactamase Enzymes

Pharmacology

• Cefixime is Bactericidal
• Broad Spectrum Antibiotic
• Interferes with Bacterial Cell Wall Synthesis
• Stable in Presence of Beta-lactamase Enzyme
• Approximately 40-50% Absorption Rate

Dosage & Administration

• Usual 7 to 14 Day Course of Treatment
• Recommended Dosage for Adults and Children over 10 Years
• Dosage Recommendations for Elderly and Children
• Special Dosage for Typhoid
• Dosage in Renal Impairment

Interaction

• Increases in Prothrombin Times in Some Patients
• Caution in Patients Receiving Anticoagulant Therapy

Contraindications

• Hypersensitivity to Cephalosporin Antibiotics

Side Effects

• Majority of Adverse Reactions Are Mild and Self-limiting
• Gastrointestinal Disturbances
• Central Nervous System Reactions
• Hypersensitivity Reactions
• Hematological and Clinical Chemistry Reactions

Pregnancy & Lactation

• No Adequate and Well-Controlled Studies in Pregnant Women
• Cautious Use During Pregnancy if Clearly Needed
• Unknown Excretion in Human Milk
• Caution When Administered to Nursing Women

Precautions & Warnings

• Caution in Patients with Hypersensitivity to Other Drugs
• Partial Cross-Allergenicity with Penicillins
• Caution in Patients with Markedly Impaired Renal Function
• Altered Colon Flora and Risk of Clostridium Difficile Overgrowth
• Not Recommended for Use in Pregnancy or Nursing Mothers

Overdose Effects

• Gastric Lavage Indication
• No Specific Antidote
• No Significant Removal by Hemodialysis or Peritoneal Dialysis
• Adverse Reactions in Healthy Adult Volunteers

Therapeutic Class

• Third Generation Cephalosporins

Storage Conditions

• Store Below 30°C Temperature
• Protect from Light and Moisture
• Keep Out of Reach of Children

Chemical Structure

• Molecular Formula: C16H15N5O7S2

Polyxim 100 mg/5 ml Suspension

• Antibiotic for Bacterial Infections
• Does Not Work for Viral Infections
• Used for Various Conditions Such as Urinary Tract Infection, Tonsillitis, Pharyngitis, and Bronchitis

Side Effects of Polyxim 100 mg/5 ml Suspension

• Diarrhea
• Abdominal Pain
• Dark or Clay-Colored Stools
• Swelling of Face, Lips, Eyelids, Tongue, Hands, and Feet
• Dizziness
• Acid or Sour Stomach
• Excessive Gas in the Stomach
• Heartburn
• Indigestion
• Redness of the Skin
• Chest Pain
• Sore Throat
• Unusual Tiredness

Storage and Disposal Instructions for Polyxim 100 mg/5 ml Suspension

• Keep in Cool Dry Place and Original Pack
• Keep Unreachable to Children and Pets
• Proper Disposal of Expired and Unused Medications

Usage in Infants for Polyxim 100 mg/5 ml Suspension

• Safety Not Established for Newborns or Infants Ageing Less than 6 Months

Dietary Instructions for Polyxim 100 mg/5 ml Suspension

• Continue Normal Diet Unless Advised Otherwise by Doctor

Similarity to Penicillin for Polyxim 100 mg/5 ml Suspension

• Partial Cross-Allergenicity with Penicillins

Effect on Diarrhea for Polyxim 100 mg/5 ml Suspension

• Known Side Effect Associated with Higher Doses

Effect on Constipation for Polyxim 100 mg/5 ml Suspension

• Unusual Side Effect; Consult Doctor if Persistent and Related to Medication Ingestion

Effect on Contraception for Polyxim 100 mg/5 ml Suspension

• No Clinically Proven Interactions with Contraceptive Medications

Usage with Acetaminophen for Polyxim 100 mg/5 ml Suspension

• No Clinically Proven Interactions with Acetaminophen (Paracetamol); Consult Doctor Before Concurrent Use

Polyxim 100 mg/5 ml Suspension Onset of Action

• Begins Working Soon After Ingestion; Takes a Few Days to Fully Relieve Symptoms; Finish Full Medication Course

Effectiveness of Polyxim 100 mg/5 ml Suspension

• Inform Doctor if No Improvement After Completing Full Course of Treatment

Quick Tips for Polyxim 100 mg/5 ml Suspension

• Complete Full Course of Treatment Even if Feeling Better
• Take with Food to Avoid Upset Stomach
• Discontinue and Inform Doctor if Allergic Reaction Occurs

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