Rofixim-DS 200 mg/5 ml (Powder for Suspension)

Indications

• Orally active cephalosporin antibiotic
• Bactericidal activity against Gram-positive and Gram-negative organisms
• Treatment for acute infections
• Efficacy against Streptococcus pneumonia, Escherichia coli, Klebsiella species, and more

Pharmacology

• Third generation semisynthetic cephalosporin antibiotic
• Bactericidal action at achievable plasma concentrations
• Interferes in bacterial cell wall synthesis
• High stability in presence of Beta-lactamase enzyme

Dosage & Administration

• Usual course of treatment is 7 days
• Recommended adult dosage is 200-400 mg daily
• Dosage adjustments for children based on age and weight
• Dosage adjustments for elderly and patients with renal impairment

Interaction

• Increases in prothrombin times in some patients
• Caution with anticoagulant therapy

Contraindications

• Hypersensitivity to cephalosporin antibiotics

Side Effects

• Mostly mild and self-limiting adverse reactions
• Common gastrointestinal disturbances like diarrhea
• Less frequent side effects include headache, dizziness, and nausea
• Possible hematological and clinical chemistry reactions

Pregnancy & Lactation

• Limited data on use in pregnant women
• Caution advised during pregnancy and lactation

Precautions & Warnings

• Caution in patients with hypersensitivity to other drugs
• Partial cross-allergenicity with penicillins
• Care with severely impaired renal function
• Potential for antibiotic-associated diarrhea

Overdose Effects

• Gastric Lavage may be indicated
• No specific antidote available
• Limited removal by hemodialysis or peritoneal dialysis

Therapeutic Class

• Third generation Cephalosporins

Storage Conditions

• Store below 30°C temperature
• Protect from light and moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C16H15N5O7S2
• Chemical Structure provided in image format

Common Questions

• Uses of Rofixim-DS 200 mg/5 ml Syrup
• Side effects of Rofixim-DS 200 mg/5 ml Syrup
• Storage and disposal instructions
• Safety in infants
• Interaction with contraception
• Concurrent use with acetaminophen
• Symptom relief duration

Special Dietary Instructions

• Continue normal diet unless advised otherwise

Absorption

• Not significantly influenced by food intake

Duration of Treatment

• Usual duration is 7 days, extendable up to 14 days if required

Renal Impairment Dosage Adjustment

• Normal dose for creatinine clearances of 20 ml/min or greater
• Dose limitation in clearances less than 20 ml/min

Gastrointestinal Side Effects

• Diarrhea and stool changes most common
• Nausea, abdominal pain, dyspepsia, vomiting also reported

Hypersensitivity Reactions

• Allergies in form of rash, pruritis, urticaria
• Hypersensitivity reactions typically resolve upon discontinuation

Hematological Reactions

• Thrombocytopenia, leukopenia, and eosinophilia reported

Gastric Lavage

• May be indicated in cases of overdose

Human Milk Excretion

• Excretion in human milk unknown, caution in nursing women

Cross-Allergenicity

• Partial cross-allergenicity between penicillins and cephalosporins

Colon Flora Alteration

• Use of broad spectrum antibiotics may disrupt normal colon flora

Prevention of Clostridia Overgrowth

• Risk of Clostridium difficile-associated diarrhea

Limited Studies in Pregnant Women

• Insufficient data for pregnant women, cautious use recommended

Chemical Stability

• High stability in presence of Beta-lactamase enzyme

Absorption Rates

• Approximately 40% to 50% absorption rate regardless of food intake

Age-Specific Dosage Recommendations

• Dosage recommendations vary by age group and weight

Infection Susceptibility

• Resistance to penicillins and some cephalsporins may not apply to Cefixime
• Susceptibility to Cefixime in organisms resistant to other antibiotics

Capillary Leakage Syndrome

• Care in patients with history of capillary leakage syndrome

Educating Patients

• Inform patients of potential side effects like diarrhea and gastrointestinal discomfort

Treatment Courses

• Typical treatment duration is 7 days, extendable based on response

Administration Recommendations

• Administer with caution to penicillin-sensitive patients

Targeted Bacteria

• Bactericidal action against broad spectrum of gram positive and gram negative bacteria

Clinical Efficacy

• Demonstrated efficacy against commonly occurring pathogens
• Effective in upper and lower respiratory tract infections

Safety in Elderly

• Elderly patients may require dosage adjustments based on renal function

Symptom Relief

• May take a few days to alleviate symptoms completely

Other Possible Reactions

• Genital pruritis, vaginitis, and other miscellaneous reactions reported

Warnings in Renal Impairment

• Dose adjustments required in patients with impaired renal function

Gastrointestinal Disturbances

• Commonly associated side effects include nausea, abdominal pain, and flatulence

Stability in Beta-lactamase Enzymes

• High stability in presence of Beta-lactamase enzymes

Adequate Studies

• Limited clinical studies in pregnant women

Avoidance of Alcohol

• Caution against consuming alcohol during treatment

Dosage Recommendations for Children

• Dosage recommendations vary by age and weight in children

Usage in Typhoid

• Specific dosage recommendations for treatment of typhoid

Storage Precautions

• Protect from light and moisture to maintain stability

Interaction with Contraceptives

• No evidence suggesting interaction with contraceptive medications

Related Brands

• Fixim 200 mg (Capsule) - reman-drug-laboratories-ltd
• Orcef 400 mg (Capsule) - renata-limited
• Orcef DS 200 mg/5 ml (Powder for Suspension) - renata-limited
• Sonexim 200 mg (Capsule) - sn-pharmaceutical-ltd
• Sonexim 100 mg/5 ml (Powder for Suspension) - sn-pharmaceutical-ltd