Ometac 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Navana pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral administration
- Benign gastric and duodenal ulcer dosage regimen
- NSAID-associated duodenal or gastric ulcer dosage regimen
- Gastro-esophageal reflux disease dosage regimen
- Long-term management of acid reflux disease dosage regimen
- Acid-related dyspepsia dosage regimen
- Prophylaxis of acid aspiration dosage regimen
- Zollinger-Ellison syndrome dosage regimen
- Helicobacter pylori eradication regimen in peptic ulcer disease dosage regimen
- Paediatric use in severe ulcerating reflux esophagitis dosage regimen
- IV Injection administration
- Prophylaxis of acid aspiration with IV injection
- Administration of Omeprazole IV for duodenal ulcer, gastric ulcer or reflux oesophagitis
- Zollinger-Ellison syndrome (ZES) treatment using IV injection
- Administration of IV Infusion
- IV Infusion over a period of 20-30 minutes or more
- Interaction with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, amoxicillin, metronidazole, pheytoin, coagulation time, plasma concentrations
- Not affected by alcohol or food
- No evidence of interaction with piroxicam, diclofenac
- Simultaneous treatment with digoxin
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
Interaction
- Decreased intragastric acidity affecting ketoconazole absorption
- Metabolism through cytochrome P450 affecting diazepam, phenytoin, warfarin elimination
- Plasma concentrations increase during concomitant administration
- No evidence of interaction with various compounds
Contraindications
- Known hypersensitivity
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, pruritus, photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis, paraesthesia
- Dizziness, light headedness, feeling faint, somnolence, insomnia, vertigo
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Other side effects such as blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, hepatic failure, increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or the health of the fetus/newborn child
- Use during pregnancy
- No information available on passage into breast milk or its effects on the neonate
- Discontinuation of breastfeeding if use is considered essential
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use of clopidogrel
- Potential increased risk for osteoporosis-related fractures
- Atrophic gastritis in patients treated long-term
- Potential methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
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