Zedoxim 20 mg/ml (Pediatric Drops)

15 ml bottle: ৳ 60.00

Medicine Details

Category Details
Generic Cefpodoxime proxetil
Company Globe pharmaceuticals ltd
Also available as
Zedoxim 40 mg suspension Zedoxim 100 mg capsule Zedoxim 200 mg capsule

Indications

  • Treatment of acute otitis media caused by specific bacteria
  • Treatment of pharyngitis/tonsillitis caused by specific bacteria
  • Treatment of acute maxillary sinusitis caused by specific bacteria
  • Treatment of community acquired pneumonia caused by specific bacteria
  • Treatment of acute bacterial exacerbation of chronic bronchitis caused by specific bacteria
  • Treatment of skin and skin structure infections caused by specific bacteria
  • Treatment of uncomplicated urinary tract infections caused by specific bacteria
  • Treatment of uncomplicated gonorrhea caused by specific bacteria
  • Treatment of rectal gonococcal infections in women caused by specific bacteria

Pharmacology

  • Oral 3rd generation cephalosporin
  • Stable to beta lactamases
  • Activity against Gram negative and Gram positive bacteria
  • Prodrug with active metabolite as Cefpodoxime
  • Approximately 29 to 33% excreted unchanged in urine

Dosage & Administration

  • Specific dosage for adults and adolescents for various infections
  • Specific dosage for infants and pediatric patients for specific infections
  • Dosing intervals adjustment for patients with severe renal impairment
  • No dose adjustment necessary for patients with liver cirrhosis

Interaction

  • Interaction with antacids leading to reduction in peak plasma level and absorption
  • Inhibition of renal excretion by probenecid resulting in increased AUC
  • Need for close monitoring of renal function when administered concomitantly with nephrotoxic drugs

Contraindications

  • Contraindicated in patients with known allergy to Cefpodoxime or cephalosporin antibiotics

Side Effects

  • Common side effects include diarrhea, nausea, skin & vaginal fungal infection, abdominal pain, headache, chest pain, myalgia, dyspepsia, dizziness, vertigo, cough
  • Higher incidence of fungal skin rash in children than in adults

Pregnancy & Lactation

  • Not teratogenic or embryocidal in animal trials
  • No adequate and well-controlled study in pregnant women
  • Use during pregnancy only if clearly needed
  • Excreted in human milk, decision needed regarding breastfeeding vs discontinuing the drug

Precautions & Warnings

  • Reduced total daily dose in patients with reduction in urinary output due to renal insufficiency
  • Caution with concurrent treatment with potent diuretics
  • Prolonged use may result in overgrowth of non-susceptible organisms
  • Repeated evaluation of patient's condition essential

Therapeutic Class

  • Third generation cephalosporins

Reconstitution

  • Instructions for reconstituting 50 ml suspension
  • Shake well before each use
  • Storage recommendations for reconstituted suspension

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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