Sedox 40 mg/5 ml (Powder for Suspension)

50 ml bottle: ৳ 98.00

Medicine Details

Category Details
Generic Cefpodoxime proxetil
Company Orbit pharmaceuticals ltd

Indications

  • Treatment of acute otitis media
  • Treatment of pharyngitis/tonsillitis
  • Treatment of acute maxillary sinusitis
  • Treatment of community acquired pneumonia
  • Treatment of acute bacterial exacerbation of chronic bronchitis
  • Treatment of skin and skin structure infections
  • Treatment of uncomplicated urinary tract infections
  • Treatment of uncomplicated gonorrhea
  • Treatment of rectal gonococcal infections in women

Pharmacology

  • Oral 3rd generation cephalosporin
  • Good stability to beta lactamases
  • Activity against Gram negative and Gram positive bacteria
  • Presence of active metabolite Cefpodoxime
  • Approximately 29 to 33% excretion in urine in 12 hours

Dosage & Administration

  • Adults and Adolescents (13 years and older):
    • Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days
    • Acute maxillary sinusitis: 200 mg 12 hourly, 10 days
    • Community-acquired pneumonia: 200 mg 12 hourly, 14 days
    • Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days
    • Skin and skin structure: 400 mg 12 hourly, 7 to 14 days
    • Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days
    • Uncomplicated gonorrhea: single dose of 200 mg
    • Rectal gonococcal infections in women: single dose of 200 mg
  • Infants and Pediatric Patients (2 months to 12 years):
    • Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days
    • Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days
    • Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days
  • Patients with renal dysfunction: Dosing intervals should be increased to 24 hourly for severe renal impairment (creatinine clearance <30ml/min)
  • Patients with liver cirrhosis: No dose adjustment necessary

Interaction

  • Reduced absorption with concomitant administration of high doses of antacids or H2 blockers
  • Renal excretion inhibition with probenecid
  • Close monitoring advised when administered with nephrotoxic drugs

Contraindications

  • Known allergy to Cefpodoxime or cephalosporin group of antibiotics

Side Effects

  • Diarrhea
  • Nausea
  • Skin and vaginal fungal infection
  • Abdominal pain
  • Headache
  • Chest pain
  • Myalgia
  • Dyspepsia
  • Dizziness
  • Vertigo
  • Cough

Pregnancy & Lactation

  • Neither teratogenic nor embryocidal in animal trial
  • Use during pregnancy only if clearly needed
  • Excreted in human milk, decision should be made whether to discontinue breastfeeding or drug

Precautions & Warnings

  • Total daily dose reduction in patients with transient or persistent reduction in urinary output
  • Caution in patients receiving concurrent treatment with potent diuretics
  • Prolonged use may result in overgrowth of non-susceptible organisms
  • Repeated evaluation of the patient’s condition is essential

Therapeutic Class

Third generation Cephalosporins

Reconstitution

Instructions for reconstituting the suspension

Storage Conditions

Keep in a dry place away from light and heat, keep out of the reach of children

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