Sedox 40 mg/5 ml (Powder for Suspension)
50 ml bottle: ৳ 98.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefpodoxime proxetil |
| Company | Orbit pharmaceuticals ltd |
Indications
- Treatment of acute otitis media
- Treatment of pharyngitis/tonsillitis
- Treatment of acute maxillary sinusitis
- Treatment of community acquired pneumonia
- Treatment of acute bacterial exacerbation of chronic bronchitis
- Treatment of skin and skin structure infections
- Treatment of uncomplicated urinary tract infections
- Treatment of uncomplicated gonorrhea
- Treatment of rectal gonococcal infections in women
Pharmacology
- Oral 3rd generation cephalosporin
- Good stability to beta lactamases
- Activity against Gram negative and Gram positive bacteria
- Presence of active metabolite Cefpodoxime
- Approximately 29 to 33% excretion in urine in 12 hours
Dosage & Administration
- Adults and Adolescents (13 years and older):
- Pharyngitis/tonsillitis: 100 mg 12 hourly, 5 to 10 days
- Acute maxillary sinusitis: 200 mg 12 hourly, 10 days
- Community-acquired pneumonia: 200 mg 12 hourly, 14 days
- Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly, 10 days
- Skin and skin structure: 400 mg 12 hourly, 7 to 14 days
- Uncomplicated urinary tract infection: 100 mg 12 hourly, 7 days
- Uncomplicated gonorrhea: single dose of 200 mg
- Rectal gonococcal infections in women: single dose of 200 mg
- Infants and Pediatric Patients (2 months to 12 years):
- Acute otitis media: 5 mg/kg body weight 12 hourly, 5 days
- Pharyngitis /tonsillitis: 5 mg/kg body weight 12 hourly, 5 to 10 days
- Acute maxillary sinusitis: 5 mg/kg body weight 12 hourly, 10 days
- Patients with renal dysfunction: Dosing intervals should be increased to 24 hourly for severe renal impairment (creatinine clearance <30ml/min)
- Patients with liver cirrhosis: No dose adjustment necessary
Interaction
- Reduced absorption with concomitant administration of high doses of antacids or H2 blockers
- Renal excretion inhibition with probenecid
- Close monitoring advised when administered with nephrotoxic drugs
Contraindications
- Known allergy to Cefpodoxime or cephalosporin group of antibiotics
Side Effects
- Diarrhea
- Nausea
- Skin and vaginal fungal infection
- Abdominal pain
- Headache
- Chest pain
- Myalgia
- Dyspepsia
- Dizziness
- Vertigo
- Cough
Pregnancy & Lactation
- Neither teratogenic nor embryocidal in animal trial
- Use during pregnancy only if clearly needed
- Excreted in human milk, decision should be made whether to discontinue breastfeeding or drug
Precautions & Warnings
- Total daily dose reduction in patients with transient or persistent reduction in urinary output
- Caution in patients receiving concurrent treatment with potent diuretics
- Prolonged use may result in overgrowth of non-susceptible organisms
- Repeated evaluation of the patient’s condition is essential
Therapeutic Class
Third generation Cephalosporins
Reconstitution
Instructions for reconstituting the suspension
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children