Ometor 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 4.00 (6 x 10: ৳ 240.00)
Strip Price: ৳ 40.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Astra biopharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg daily in severe or recurrent cases
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer for 4-8 weeks
- 40 mg once daily for gastro-esophageal reflux disease for 4-8 weeks
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for 2-4 weeks for acid-related dyspepsia
- 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
- Initially 60 mg once daily for Zollinger-Ellison syndrome, usual range 20-120 mg daily
- 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
- 10-20 mg once daily for 4-12 weeks for severe ulcerating reflux esophagitis (Child>1 year)
Administration
- IV Injection for prophylaxis of acid aspiration
- IV Infusion over 20-30 minutes
- Slow intravenous injection over at least 2 to 5 minutes at a maximum rate of 4 ml/minute
- Use within 4 hours of reconstitution for IV injection
- Use within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose for IV infusion
- Reconstituted solution should not be mixed or co-administered with any other drug
Interaction
- Decreased intragastric acidity may reduce the absorption of ketoconazole
- Metabolized in the liver through cytochrome P450, can delay the elimination of diazepam, phenytoin and warfarin
- Increased plasma concentrations during concomitant administration with clarithromycin for H. pylori eradication
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, alcohol or food
Contraindications
- Known hypersensitivity to Omeprazole
- Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia
- Diarrhoea, headache
- Gastrointestinal reactions: constipation, nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
- Paraesthesia, dizziness, lightheadedness, feeling faint
- Somnolence, insomnia, vertigo
- Reversible mental confusion, agitation, depression, hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia
- Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
- Hepatic effects: hepatitis with or without jaundice, interstitial nephritis, hepatic failure
Pregnancy & Lactation
- No adverse effects on pregnancy or on the health of the fetus/newborn child in three prospective epidemiological studies
- Use during pregnancy considered safe
- No information available on the passage of Omeprazole into breast milk or its effects on the neonate
- Breast-feeding should be discontinued if Omeprazole use is considered essential
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- PPI therapy may be associated with an increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in patients treated long-term
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat, keep out of the reach of children
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