Omevir 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (60's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Omeprazole
Company Virgo pharmaceuticals ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • Treatment of NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Treatment of Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Substituted benzimidazole
  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • Oral administration
  • Benign gastric and duodenal ulcer dosage
  • NSAID-associated duodenal or gastric ulcer dosage
  • Gastro-esophageal reflux disease dosage
  • Long-term management of acid reflux disease dosage
  • Acid-related dyspepsia dosage
  • Prophylaxis of acid aspiration dosage
  • Zollinger-Ellison syndrome dosage
  • Helicobacter pylori eradication regimen dosage
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Instruction for IV injection
  • Instruction for IV infusion
  • Intravenous administration only
  • Intravenous infusion over a period of 20-30 minutes or more

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Increased plasma concentrations during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids
  • Increased bioavailability of digoxin during simultaneous treatment with omevir

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer malignancy

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia
  • Dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia
  • Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
  • Bronchospasm, encephalopathy, hepatitis with or without jaundice, interstitial nephritis, hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • Suitable for use during pregnancy
  • Unknown passage into breast milk
  • Discontinuation of breastfeeding if omeprazole use is essential
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in patients treated long-term with omevir
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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