Omevir 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (60's pack: ৳ 300.00)
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Virgo pharmaceuticals ltd |
Indications
- Treatment of gastric and duodenal ulcer
- Treatment of NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Treatment of gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Treatment of acid-related dyspepsia
- Treatment of severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Treatment of Zollinger-Ellison syndrome
- Treatment of Helicobacter pylori-induced peptic ulcer
Pharmacology
- Substituted benzimidazole
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- Oral administration
- Benign gastric and duodenal ulcer dosage
- NSAID-associated duodenal or gastric ulcer dosage
- Gastro-esophageal reflux disease dosage
- Long-term management of acid reflux disease dosage
- Acid-related dyspepsia dosage
- Prophylaxis of acid aspiration dosage
- Zollinger-Ellison syndrome dosage
- Helicobacter pylori eradication regimen dosage
- Pediatric use in severe ulcerating reflux esophagitis
Administration
- Instruction for IV injection
- Instruction for IV infusion
- Intravenous administration only
- Intravenous infusion over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
- Increased plasma concentrations during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, or antacids
- Increased bioavailability of digoxin during simultaneous treatment with omevir
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer malignancy
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhoea and headache
- Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia
- Dizziness, light headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia
- Leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock, malaise, fever
- Bronchospasm, encephalopathy, hepatitis with or without jaundice, interstitial nephritis, hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or on the health of the fetus/newborn child
- Suitable for use during pregnancy
- Unknown passage into breast milk
- Discontinuation of breastfeeding if omeprazole use is essential
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted in patients treated long-term with omevir
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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