Omezole 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.00 (50's pack: ৳ 200.00)

Medicine Details

Category	Details
Generic	Omeprazole
Company	Medimet pharmaceuticals ltd

Indications

Gastric and duodenal ulcer
NSAID-associated duodenal and gastric ulcer
As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
Gastro-esophageal reflux disease
Long-term management of acid reflux disease
Acid-related dyspepsia
Severe ulcerating reflux esophagitis
Prophylaxis of acid aspiration during general anesthesia
Zollinger-Ellison syndrome
Helicobacter pylori-induced peptic ulcer

Pharmacology

Inhibitor of gastric acid secretion; blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system; onset of antisecretory effect occurs within one hour; maximum effect within two hours; inhibition of secretion lasts up to 72 hours

Dosage

Oral
IV Injection
Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks
Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks
Long-term management of acid reflux disease: 10-20 mg daily
Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily
Paediatric use in severe ulcerating reflux esophagitis (Child>1 year): 10-20 mg once daily for 4-12 weeks if body-weight 10-20 kg, 20-40 mg once daily for 4-12 weeks if body-weight over 20 kg

Administration

Direction for use of IV Injection: Omeprazole for intravenous administration only; should be given as a slow intravenous injection; reconstituted injection should be given slowly over a period of at least 2 to 5 minutes; Use only freshly prepared solution

Interaction

Omezole's effect on ketoconazole absorption; metabolism in the liver through cytochrome P450; potential interactions with diazepam, phenytoin, warfarin, clarithromycin, rifampicin, digoxin, citalopram, escitalopram, etc.

Contraindications

Known hypersensitivity to omeprazole; suspicion of gastric ulcer must exclude the possibility of malignancy before treatment

Side Effects

Skin rash, urticaria, and pruritus
Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
Dry mouth, stomatitis, and candidiasis
Paraesthesia
Dizziness, light headedness, and feeling faint
Somnolence, insomnia, and vertigo
Reversible mental confusion, agitation, depression, and hallucinations
Arthritic and myalgic symptoms
Other rare reactions such as blurred vision, taste disturbance, peripheral oedema, etc.

Pregnancy & Lactation

Safety in pregnancy; discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

Avoid concomitant use with clopidogrel
Possible association with increased risk for osteoporosis-related fractures
Atrophic gastritis noted occasionally in long-term usage
Potential methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat; Keep out of the reach of children