Omezole 20 mg (Capsule (Enteric Coated))
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Medimet pharmaceuticals ltd |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
Inhibitor of gastric acid secretion; blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system; onset of antisecretory effect occurs within one hour; maximum effect within two hours; inhibition of secretion lasts up to 72 hours
Dosage
- Oral
- IV Injection
- Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks in duodenal ulceration, 8 weeks in gastric ulceration
- NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks
- Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks
- Long-term management of acid reflux disease: 10-20 mg daily
- Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
- Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
- Zollinger-Ellison syndrome: Initially 60 mg once daily; usual range 20-120 mg daily
- Paediatric use in severe ulcerating reflux esophagitis (Child>1 year): 10-20 mg once daily for 4-12 weeks if body-weight 10-20 kg, 20-40 mg once daily for 4-12 weeks if body-weight over 20 kg
Administration
Direction for use of IV Injection: Omeprazole for intravenous administration only; should be given as a slow intravenous injection; reconstituted injection should be given slowly over a period of at least 2 to 5 minutes; Use only freshly prepared solution
Interaction
Omezole's effect on ketoconazole absorption; metabolism in the liver through cytochrome P450; potential interactions with diazepam, phenytoin, warfarin, clarithromycin, rifampicin, digoxin, citalopram, escitalopram, etc.
Contraindications
Known hypersensitivity to omeprazole; suspicion of gastric ulcer must exclude the possibility of malignancy before treatment
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia
- Dizziness, light headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Other rare reactions such as blurred vision, taste disturbance, peripheral oedema, etc.
Pregnancy & Lactation
Safety in pregnancy; discontinuation of breastfeeding if essential use is considered
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Possible association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in long-term usage
- Potential methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat; Keep out of the reach of children
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