Cebumax 90 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 480.00

Medicine Details

Category Details
Generic Ceftibuten dihydrate
Company General pharmaceuticals ltd
Also available as
Cebumax 400 mg capsule

Indications

  • Treatment of acute bacterial exacerbations of chronic bronchitis
  • Treatment of acute bacterial otitis media
  • Treatment of pharyngitis and tonsillitis

Pharmacology

Ceftibuten is a semi-synthetic Cephalosporin antibiotic for oral administration.

Dosage & Administration

  • Otitis Media:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
  • Tonsillitis/Pharyngitis:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
  • Bronchitis:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 days
  • Cystitis:
    • Adult Dosage: 400 mg orally every 24 hours for 7 days
    • Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 7 days
  • Pneumonia:
    • Adult Dosage: 200 mg orally every 12 hours for 7 to 14 days
    • Pediatric Dosage: >12 years: 200 mg orally every 12 hours for 7 to 14 days
  • Sinusitis:
    • Adult Dosage: 400 mg orally every 24 hours for 10 to 14 days
    • Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 to 14 days
  • Urinary tract Infection:
    • Adult Dosage: 400 mg orally every 24 hours for 10 days
    • Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days

Interaction

Theophylline & Antacid do not alter the pharmacokinetic profile of Cebumax. Ranitidine increases the Cmax & AUC of Cebumax.

Contraindications

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects

  • Nausea
  • Headache
  • Diarrhea
  • Dyspepsia
  • Dizziness
  • Abdominal pain
  • Vomiting

Pregnancy & Lactation

  • Category: Pregnancy Category B
  • Usage in Pregnancy: Should be used when the benefit clearly outweighs the risk
  • Excretion in Human Milk: Caution should be exercised when administered to nursing women

Precautions & Warnings

  • Prolonged treatment may result in possible emergence and overgrowth of resistant organisms
  • Dose may require adjustment in patients with varying degrees of renal insufficiency
  • Cautious use in individuals with a history of gastrointestinal disease, particularly colitis

Use in Special Populations

  • Renal Impairment:
    • CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a day
    • CrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a day
  • Hepatic Impairment: Dose adjustment is not necessary

Therapeutic Class

Third generation Cephalosporins

Reconstitution

  • Contains purified water and granules
  • Requires shaking before use
  • Prepared suspension to be consumed within 14 days of preparation if kept in a refrigerator

Storage Conditions

Store below 25°C, protected from light and moisture. Suspension may be used for 14 days after reconstitution when stored at 2°C to 8°C.

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