Tibucef 400 mg (Capsule)

Unit Price: ৳ 120.00 (1 x 6: ৳ 720.00)

Strip Price: ৳ 720.00

Medicine Details

Category	Details
Generic	Ceftibuten dihydrate
Company	Globe pharmaceuticals ltd
Also available as	Tibucef 90 mg suspension

Indications

Acute Bacterial Exacerbations of Chronic Bronchitis
Acute Bacterial Otitis Media
Pharyngitis and Tonsillitis

Pharmacology

Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis.

Dosage & Administration

Otitis Media:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
Tonsillitis/Pharyngitis:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
Bronchitis:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 days
Cystitis:
- Adult Dosage: 400 mg orally every 24 hours for 7 days
- Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 7 days
Pneumonia:
- Adult Dosage: 200 mg orally every 12 hours for 7 to 14 days
- Pediatric Dosage: >12 years: 200 mg orally every 12 hours for 7 to 14 days
Sinusitis:
- Adult Dosage: 400 mg orally every 24 hours for 10 to 14 days
- Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 to 14 days
Urinary tract Infection:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days

Interaction

Theophylline & Antacid do not alter the pharmacokinetic profile of Tibucef
Ranitidine increases the Cmax & AUC of Tibucef.

Contraindications

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects

Nausea
Headache
Diarrhea
Dyspepsia
Dizziness
Abdominal pain
Vomiting

Pregnancy & Lactation

Pregnancy Category B. There are no controlled data on the use of Ceftibuten in pregnant women. Ceftibuten should be used in pregnancy only when the benefit clearly outweighs the risk. It is not known whether Ceftibuten (recommended dosage) is excreted in human milk. Because many drugs are excreted in human milk, caution should be excercised when Ceftibuten is administered to nursing women.

Precautions & Warnings

Prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. The dose of Tibucef may require adjustment in patients with varying degrees of renal insufficiency. Tibucef should be prescribed with caution to individuals with a history of gastrointestinal disease, particularly colitis.

Use in Special Populations

Renal Impairment:
- CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a day
- CrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a day
Hepatic Impairment: Dose adjustment is not necessary.

Therapeutic Class

Third generation Cephalosporins

Reconstitution

The small bottle contains purified water and large bottle contains granules
Pour the purified water completely into large bottle
Tighten the cap of large bottle and shake the bottle for at least one minute
Use a measuring cup or dropper for reconstituted suspension
Prepared suspension to be consumed within 14 days of preparation if kept in a refrigerator. Shake the bottle well each time before use.

Storage Conditions

Store below 25°C, protected from light and moisture. For Suspension: After reconstitution, the suspension may be used for 14 days while stored at 2°C to 8°C. Keep out of reach of children.