Zoventa DS 180 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 800.00

Medicine Details

Category	Details
Generic	Ceftibuten dihydrate
Company	Healthcare pharmaceuticals ltd
Also available as	Zoventa 200 mg capsule Zoventa 400 mg capsule Zoventa 90 mg suspension

Indications

Mild-to-moderate infections treatment
Acute Bacterial Exacerbations of Chronic Bronchitis
Acute Bacterial Otitis Media
Pharyngitis and Tonsillitis

Pharmacology

Ceftibuten is a semi-synthetic Cephalosporin antibiotic for oral administration. It exerts bactericidal action by binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis.

Dosage & Administration

Adult Dosage for Otitis Media: 400 mg orally every 24 hours for 10 days
Pediatric Dosage for Otitis Media: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
Adult Dosage for Bronchitis: 400 mg orally every 24 hours for 10 days
Pediatric Dosage for Bronchitis: >12 years: 400 mg orally every 24 hours for 10 days

Interaction

Theophylline & Antacid do not alter the pharmacokinetic profile of Zoventa DS. Ranitidine increases the Cmax & AUC of Zoventa DS.

Contraindications

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects

Nausea
Headache
Diarrhea
Dyspepsia
Dizziness
Abdominal Pain
Vomiting

Pregnancy & Lactation

Pregnancy Category B. Use in pregnancy only when the benefit outweighs the risk. Caution should be exercised when administered to nursing women.

Precautions & Warnings

Prolonged treatment may result in emergence of resistant organisms. Dose adjustment in patients with varying degrees of renal insufficiency. Prescribed with caution to individuals with a history of gastrointestinal disease.

Use in Special Populations

Renal Impairment:
- CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a day
- CrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a day
Hepatic Impairment: Dose adjustment not necessary

Therapeutic Class

Third generation Cephalosporins

Reconstitution

Steps:
- The small bottle contains purified water and large bottle contains granules
- Pour the purified water completely into large bottle
- Tighten the cap of large bottle and shake the bottle for at least one minute
- Use a measuring cup or dropper for reconstituted suspension
Usage: Prepared suspension to be consumed within 14 days of preparation if kept in a refrigerator. Shake the bottle well each time before use.

Storage Conditions

Store below 25°C, protected from light and moisture. After reconstitution, the suspension may be used for 14 days while stored at 2° to 8°C. Keep out of reach of children.