Zoventa DS 180 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftibuten dihydrate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Mild-to-moderate infections treatment
- Acute Bacterial Exacerbations of Chronic Bronchitis
- Acute Bacterial Otitis Media
- Pharyngitis and Tonsillitis
Pharmacology
Ceftibuten is a semi-synthetic Cephalosporin antibiotic for oral administration. It exerts bactericidal action by binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis.
Dosage & Administration
- Adult Dosage for Otitis Media: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage for Otitis Media: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days
- Adult Dosage for Bronchitis: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage for Bronchitis: >12 years: 400 mg orally every 24 hours for 10 days
Interaction
Theophylline & Antacid do not alter the pharmacokinetic profile of Zoventa DS. Ranitidine increases the Cmax & AUC of Zoventa DS.
Contraindications
Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Side Effects
- Nausea
- Headache
- Diarrhea
- Dyspepsia
- Dizziness
- Abdominal Pain
- Vomiting
Pregnancy & Lactation
Pregnancy Category B. Use in pregnancy only when the benefit outweighs the risk. Caution should be exercised when administered to nursing women.
Precautions & Warnings
Prolonged treatment may result in emergence of resistant organisms. Dose adjustment in patients with varying degrees of renal insufficiency. Prescribed with caution to individuals with a history of gastrointestinal disease.
Use in Special Populations
- Renal Impairment:
- CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a day
- CrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a day
- Hepatic Impairment: Dose adjustment not necessary
Therapeutic Class
Third generation Cephalosporins
Reconstitution
- Steps:
- The small bottle contains purified water and large bottle contains granules
- Pour the purified water completely into large bottle
- Tighten the cap of large bottle and shake the bottle for at least one minute
- Use a measuring cup or dropper for reconstituted suspension
- Usage: Prepared suspension to be consumed within 14 days of preparation if kept in a refrigerator. Shake the bottle well each time before use.
Storage Conditions
Store below 25°C, protected from light and moisture. After reconstitution, the suspension may be used for 14 days while stored at 2° to 8°C. Keep out of reach of children.