Cefamax 400 mg (Capsule)

Unit Price: ৳ 120.00 (2 x 4: ৳ 960.00)

Strip Price: ৳ 480.00

Medicine Details

Category	Details
Generic	Ceftibuten dihydrate
Company	Incepta pharmaceuticals ltd
Also available as	Cefamax 90 mg suspension Cefamax ds 180 mg suspension Cefamax 200 mg capsule

Indications

Mild-to-moderate infections treatment
Exacerbations of chronic bronchitis
Bacterial otitis media
Pharyngitis and tonsillitis

Pharmacology

Ceftibuten is a semi-synthetic Cephalosporin antibiotic for oral administration. It exerts bactericidal action by binding to essential target proteins of the bacterial cell wall, leading to inhibition of cell-wall synthesis.

Dosage & Administration

Otitis Media:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >6 months: 9 mg/kg/day (max 400 mg) every 24 hours for 10 days
Tonsillitis/Pharyngitis:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >6 months: 9 mg/kg/day (max 400 mg) every 24 hours for 10 days
Bronchitis:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 days
Cystitis:
- Adult Dosage: 400 mg orally every 24 hours for 7 days
- Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 7 days
Pneumonia:
- Adult Dosage: 200 mg orally every 12 hours for 7 to 14 days
- Pediatric Dosage: >12 years: 200 mg orally every 12 hours for 7 to 14 days
Sinusitis:
- Adult Dosage: 400 mg orally every 24 hours for 10 to 14 days
- Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 to 14 days
Urinary Tract Infection:
- Adult Dosage: 400 mg orally every 24 hours for 10 days
- Pediatric Dosage: >6 months: 9 mg/kg/day (max 400 mg) every 24 hours for 10 days

Interaction

Theophylline & Antacid do not alter pharmacokinetic profile of Cefamax. Ranitidine increases the Cmax & AUC of Cefamax.

Contraindications

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects

Nausea
Headache
Diarrhea
Dyspepsia
Dizziness
Abdominal pain
Vomiting

Pregnancy & Lactation

Pregnancy Category B. Caution should be exercised when administered to nursing women.

Precautions & Warnings

Prolonged treatment may result in emergence of resistant organisms. Careful observation of the patient is essential. Dose may require adjustment in patients with renal insufficiency. Caution in individuals with history of gastrointestinal disease.

Use in Special Populations

Renal Impairment:
- CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a day
- CrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a day
Hepatic Impairment: Dose adjustment is not necessary

Therapeutic Class

Third generation Cephalosporins

Reconstitution

The small bottle contains purified water and large bottle contains granules
Pour the purified water completely into large bottle
Tighten the cap of large bottle and shake the bottle for at least one minute
Use a measuring cup or dropper for reconstituted suspension
Prepared suspension to be consumed within 14 days of preparation if kept in a refrigerator. Shake the bottle well each time before use.

Storage Conditions

Store below 25°C, protected from light and moisture. After reconstitution, the suspension may be used for 14 days while stored at 2°C to 8°C. Keep out of reach of children.