Omirex 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.02 (5 x 4: ৳ 160.40)
Strip Price: ৳ 32.08
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Jayson pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg daily for severe or recurrent cases of ulcer
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for 4-8 weeks for Gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 40 mg on the preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
- Initially 60 mg once daily for Zollinger-Ellison syndrome
- 20 mg twice daily in association with antimicrobial agents for Helicobacter pylori eradication
- 10-40 mg once daily for 4-12 weeks in pediatric use for severe ulcerating reflux esophagitis
Administration
- Omeprazole IV injection for intravenous administration only
- IV injection given slowly over a period of 5 minutes
- IV infusion given over a period of 20-30 minutes or more
- Reconstituted solution used within 4 hours for IV injection and 12 hours for IV infusion
- Solution not mixed or co-administered in the same infusion set with any other drug
Interaction
- Decreased intragastric acidity may reduce absorption of ketoconazole during treatment
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin and warfarin
- Plasma concentrations of Omeprazole and clarithromycin are increased during concomitant administration
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin or antacids
- No evidence of interaction with piroxicam, diclofenac or naproxen
- Simultaneous treatment with Omeprazole and digoxin in healthy subjects lead to a 10% increase in the bioavailability of digoxin
Contraindications
- Known hypersensitivity to Omeprazole
- Presence of suspected gastric ulcer without excluding the possibility of malignancy
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme in isolated cases
- Diarrhoea and headache, severe enough to require discontinuation of therapy in a small number of patients
- Constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis in isolated cases
- Paraesthesia
- Dizziness, light-headedness, and faint feeling
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations in severely ill patients
- Arthritic and myalgic symptoms, resolved when therapy is stopped
- Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, and more
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or on the health of the fetus/newborn child
- Omeprazole can be used during pregnancy
- No information available on the passage of Omeprazole into breast milk or its effects on the neonate
- Breast-feeding should be discontinued if the use of Omeprazole is considered essential
- Safety and effectiveness not established in pediatric patients less than 18 years of age
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Omeprazole
- Observational studies suggest an increased risk for osteoporosis-related fractures with PPI therapy
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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