Kefuclav (125 mg+31.25 mg)/5 ml (Powder for Suspension)

70 ml bottle: ৳ 285.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Eskayef pharmaceuticals ltd
Also available as
Kefuclav 500 mg tablet Kefuclav 250 mg tablet

Title

Kefuclav 125 Suspension

Categories

  • Medicine
  • Antibiotic
  • Cephalosporin
  • Second Generation

Description

Kefuclav 125 Suspension is indicated for the treatment of infections caused by sensitive bacteria and contains Cefuroxime and Clavulanic acid. It is used for various conditions including pharyngitis, tonsillitis, sinusitis, bronchitis, skin infections, urinary tract infections, gonorrhea, pneumonia, and typhoid fever. It is well-tolerated but may cause side effects such as nausea, vomiting, diarrhea, and abdominal discomfort. It should be stored in a cool, dry place away from light and moisture.

DosageAndAdministration

  • For adolescents and adults (13 years and older): Multiple dosage regimens for different conditions (e.g., Pharyngitis/tonsillitis, Acute bacterial maxillary sinusitis, Uncomplicated skin and skin structure infections, etc.)
  • For pediatric patients (3 months to 12 years): Multiple dosage regimens for different conditions (e.g., Pharyngitis/Tonsillitis, Acute otitis media, Impetigo)

Pharmacology

Cefuroxime is a bactericidal second generation cephalosporin antibiotic active against a wide range of Gram-positive and Gram-negative susceptible organisms. Clavulanic acid is a beta-lactamase inhibitor that provides protection of Cefuroxime from degradation by beta-lactamase enzymes.

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
  • Lower respiratory tract infections including pneumoniae, caused by various bacteria
  • Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus or Streptococcus pyogenes
  • Uncomplicated urinary tract infections caused by E.coli or Klebsiella pneumoniae
  • Bone and Joint Infections caused by Staphylococcus aureus
  • Uncomplicated Gonorrhoea caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae
  • Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
  • Septicemia caused by various bacteria
  • Meningitis caused by various bacteria
  • Switch therapy (Injectable to oral)

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Contraindications

  • Known allergy to cephalosporin
  • Pseudomembranous Colitis

SideEffects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Prolonged administration may result in overgrowth of nonsusceptible microorganisms
  • Rarely: Renal dysfunction, anaphylaxis, angioedema, pruritis, rash, serum sickness like urticaria

PregnancyAndLactation

Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. It is excreted into the breast milk in small quantities, so the possibility of sensitizing the infant should be kept in mind.

PrecautionsAndWarnings

  • Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics
  • History of colitis

TherapeuticClass

Second generation Cephalosporins

StorageConditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

CommonlyAskedQuestions

  • Kefuclav125Syrup:
    • WhatIsIt: Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. Kefuclav 125 Syrup is indicated for the treatment of infections caused by sensitive bacteria.
    • UsedFor: Kefuclav 125 Syrup is used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.
    • TakeEffectTime: Kefuclav 125 Syrup starts working within 2-3 hours after taking it.
    • EffectDuration: The effect of Kefuclav 125 Syrup lasts for an average duration of 4-8 hours.
    • AlcoholConsumption: Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
    • HabitForming: No habit-forming tendencies were reported for Kefuclav 125 Syrup.
    • PregnancySafety: Kefuclav 125 Syrup is safe to use in pregnancy to treat bacterial infections. It is recommended to use this medicine only after consulting your doctor.
    • BreastfeedingSafety: Kefuclav 125 Syrup is safe to use during breastfeeding. It enters into breast milk at low levels.
    • QuickTips:
      • You have been prescribed Kefuclav 125 Syrup medicine to treat bacterial infections, even if they have developed resistance.
      • Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat.
      • Take it with food to avoid an upset stomach.
      • Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
      • Stop taking Kefuclav 125 Syrup and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
      • Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

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