Sharpkil Plus 250 mg+62.5 mg (Tablet)

Unit Price: ৳ 32.00 (2 x 7: ৳ 448.00)
Strip Price: ৳ 224.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company One pharma ltd
Also available as
Sharpkil plus 500 mg tablet Sharpkil plus 125 mg suspension

Title

  • Sharpkil Plus 250 mg Tablet

Categories

  • Medicine
  • Pharmaceutical
  • Antibiotic

Description

  • Cefuroxime-Clavulanic Acid tablet indicated for the treatment of infections caused by sensitive bacteria.

Dosage and administration

  • 250 mg b.i.d. for 5-10 days for Pharyngitis/Tonsillitis in adolescents and adults
  • 250 mg b.i.d. for 10 days for Acute Bacterial Maxillary Sinusitis in adolescents and adults
  • 250-500 mg b.i.d. for 10 days for Acute Bacterial Exacerbation of Chronic Bronchitis in adolescents and adults
  • 250-500 mg b.i.d. for 5-10 days for Secondary Bacterial Infections of Acute Bronchitis in adolescents and adults
  • 250-500 mg b.i.d. for 10 days for Uncomplicated Skin and Skin Structure Infections in adolescents and adults
  • 250 mg b.i.d. for 7-10 days for Uncomplicated Urinary Tract Infections in adolescents and adults
  • 1000 mg b.i.d. as a single dose for Uncomplicated Gonorrhoea in adolescents and adults
  • 250-500 mg b.i.d. for 5-10 days for Community Acquired Pneumonia in adolescents and adults
  • 500 mg b.i.d. for 10-14 days for MDR Typhoid Fever in adolescents and adults
  • 500 mg b.i.d. for 20 days for Early Lyme Disease in adolescents and adults
  • 20 mg/kg/day b.i.d for 5-10 days for Pharyngitis/Tonsillitis in pediatric patients
  • 30 mg/kg/day b.i.d for 10 days for Acute Otitis Media in pediatric patients
  • 30 mg/kg/day b.i.d for 10 days for Acute Bacterial Maxillary Sinusitis in pediatric patients
  • 30 mg/kg/day b.i.d for 10 days for Impetigo in pediatric patients

Pharmacology

  • Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains
  • Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process
  • Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus
  • Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria

Interaction

  • Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%
  • Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption

Contraindications

  • Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin
  • Cefuroxime-Clavulanic Acid is contraindicated in patients with Pseudomembranous Colitis

Side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Prolonged administration may result in overgrowth of nonsusceptible microorganisms
  • Renal dysfunction (rarely)
  • Anaphylaxis (rarely)
  • Angioedema (rarely)
  • Pruritis (rarely)
  • Rash (rarely)
  • Serum sickness like urticaria (rarely)

Pregnancy and lactation

  • Should be avoided in the first trimester if possible
  • Can be safely used in later pregnancy to treat urinary and other infections
  • Excreted into the breast milk in small quantities

Precautions and warnings

  • Should be given with care to patients receiving concurrent treatment with potent diuretics
  • Should be given with care to patients who have history of colitis

Therapeutic class

  • Second generation Cephalosporins

Storage conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light and moisture
  • Keep out of the reach of children

Common questions

  • What is Sharpkil Plus 250 mg Tablet?
  • What is Sharpkil Plus 250 mg Tablet used for?
  • How long does it take for Sharpkil Plus 250 mg Tablet to take effect?
  • How long do the effects of this medicine last?
  • Sharpkil Plus 250 mg Tablet it safe to consume alcohol while taking this medicine?
  • Is Sharpkil Plus 250 mg Tablet a habit forming medicine?
  • Can this medicine be taken during pregnancy?
  • Can Sharpkil Plus 250 mg Tablet be taken while breast-feeding?
  • You have been prescribed Sharpkil Plus 250 mg Tablet medicine to treat bacterial infections, even if they have developed resistance. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat. Take it with food to avoid an upset stomach. Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps. Stop taking Sharpkil Plus 250 mg Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it. Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non beta-lactamase producing strains)
  • Lower respiratory tract infections including pneumoniae, caused by Streptococcus pneumoniae, Haemophilus influenzae (including beta lactamase-producing strains), Klebsiella spp., Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains), Streptococcus pyogenes, E. coli
  • Acute bacterial exacerbation of chronic bronchitis and secondary bacterial infections of Acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae (beta-lactamase negative strains) or Haemophilus parainfluenzae (beta-lactamase negative strains)
  • Uncomplicated skin and skin-structure infections caused by Staphylococcus aureus (including beta-lactamase producing strains) or Streptococcus pyogenes
  • Uncomplicated urinary tract infections caused by E.coli or Klebsiella pneumoniae
  • Bone and Joint Infections caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains)
  • Uncomplicated Gonorrhoea caused by penicillinase-producing and non-penicillinase producing strains of Neisseria gonorrhoeae
  • Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
  • Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, E.coli, Haemophilus influenzae (including ampicillin-resistant strains) & Klebsiella spp.
  • Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin-resistant strains), Neisseria meningitidis & Staphylococcus aureus (penicillinase and non-penicillinase producing strains)
  • Switch therapy (Injectable to oral)

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