OP-20 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Globe pharmaceuticals ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of the antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- Oral administration
- IV Injection
- Benign gastric and duodenal ulcer dosage
- NSAID-associated duodenal or gastric ulcer dosage
- Gastro-esophageal reflux disease dosage
- Long-term management of acid reflux disease dosage
- Acid-related dyspepsia dosage
- Prophylaxis of acid aspiration dosage
- Zollinger-Ellison syndrome dosage
- Helicobacter pylori eradication regimen in peptic ulcer disease dosage
- Paediatric use in severe ulcerating reflux esophagitis dosage
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
- Intravenous administration only
- IV infusion over a period of 20-30 minutes or more
- Solution for IV injection is obtained by adding 10 ml water for injection to the vial containing powder
- IV infusion should be given as an intravenous infusion over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity affecting the absorption of ketoconazole
- Metabolism through cytochrome P450 affecting the elimination of diazepam, phenytoin, and warfarin
- Monitoring and potential dose adjustment for patients receiving warfarin or phenytoin
- Increased plasma concentrations during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
- No effect on absorption by alcohol or food
- Interaction with digoxin leading to a 10% increase in bioavailability
Contraindications
- Known hypersensitivity to Omeprazole
- Need for exclusion of malignancy when gastric ulcer is suspected
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
- Diarrhoea and headache
- Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia
- Dizziness, light-headedness, and feeling faint
- Somnolence, insomnia, and vertigo
Pregnancy & Lactation
- Results from prospective epidemiological studies indicating no adverse effects on pregnancy or fetal health
- Use during pregnancy deemed safe
- No information available on passage into breast milk or effects on the neonate
- Discontinuation of breastfeeding if essential use of Omeprazole is considered
Precautions & Warnings
- Avoid concomitant use of clopidogrel
- Potential association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treatment
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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