OP-40 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.00 (10 x 4: ৳ 320.00)
Strip Price: ৳ 32.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Globe pharmaceuticals ltd |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Specific dosages for benign gastric and duodenal ulcers
- Dosage for NSAID-associated duodenal or gastric ulcers
- Dosage for Gastro-esophageal reflux disease
- Dosage for long-term management of acid reflux disease
- Dosage for acid-related dyspepsia
- Dosage for prophylaxis of acid aspiration
- Dosage for Zollinger-Ellison syndrome
- Dosage for Helicobacter pylori eradication regimen
- Pediatric dosages for severe ulcerating reflux esophagitis
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
Interaction
- Decreased intragastric acidity affecting absorption of ketoconazole
- Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
- Monitoring and potential dose reduction for warfarin or phenytoin when co-administered
- Increased plasma concentrations during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
Contraindications
- Known hypersensitivity to omeprazole
- Need to exclude possibility of malignancy before treatment for suspected gastric ulcer
Side Effects
- Mild and reversible adverse reactions
- Reported skin rash, urticaria, pruritus, photosensitivity, bullous eruption, and erythema multiforme
- Reported gastrointestinal reactions like diarrhea, nausea/vomiting, flatulence, and abdominal pain
- Reported neurological and psychotropic effects
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child observed in prospective epidemiological studies
- Use during pregnancy considered safe
- No information available on passage into breast milk or effects on the neonate
- Breastfeeding should be discontinued if essential use of omeprazole
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Possible association with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted in patients treated long-term
- Potential methotrexate toxicities with concomitant use of PPIs
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
Related Brands
- OP-20 20 mg (Capsule (Enteric Coated)) - globe-pharmaceuticals-ltd
- Seloktil 20 mg (Capsule (Enteric Coated)) - belsen-pharmaceuticals-ltd
- Omsec 40 mg/vial (IV Injection) - techno-drugs-ltd
- Omsec 20 mg (Capsule (Enteric Coated)) - techno-drugs-ltd
- Omrazol 40 mg (Capsule (Enteric Coated)) - ad-din-pharmaceuticals-ltd