Opal 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Healthcare pharmaceuticals ltd
Also available as
Opal 40 mg capsule Opal 40 mg injection

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for 4 weeks in duodenal ulceration
  • 8 weeks in gastric ulceration
  • 40 mg daily for severe or recurrent cases
  • Maintenance dose for recurrent duodenal ulcer
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 20 mg once daily for 4-8 weeks in gastro-esophageal reflux disease
  • 40 mg once daily for 8 weeks in refractory cases of gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for 2-4 weeks in acid-related dyspepsia
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initial dose of 60 mg once daily in Zollinger-Ellison syndrome

Administration

  • Omeprazole IV injection should be given as a slow intravenous injection
  • IV infusion over a period of 20-30 minutes or more
  • Reconstituted solution should not be mixed with any other drug

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting elimination of diazepam, phenytoin, and warfarin
  • Monitoring recommended for patients receiving warfarin or phenytoin
  • Plasma concentrations of Opal and clarithromycin increased during concomitant administration

Contraindications

  • Known hypersensitivity to Omeprazole
  • Suspicion of gastric ulcer should exclude possibility of malignancy before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Dizziness, light-headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, and depression

Pregnancy & Lactation

  • No adverse effects of Omeprazole on pregnancy or fetus/newborn child
  • Use during pregnancy can be considered
  • No information available on passage into breast milk

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in patients treated long-term with Opal
  • Concomitant use with methotrexate may lead to toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat

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