Opal 40 mg/vial (IV Injection)

40 mg vial: ৳ 95.00

Medicine Details

Category Details
Generic Omeprazole
Company Healthcare pharmaceuticals ltd
Also available as
Opal 20 mg capsule Opal 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Return of secretory activity gradually over 3 to 5 days after discontinuation

Dosage

  • Dosage for various conditions specified

Administration

  • Oral administration instructions
  • IV injection administration instructions
  • IV infusion administration instructions

Interaction

  • Reduced absorption of ketoconazole during Opal treatment
  • Metabolized in the liver through cytochrome P450
  • Possible delay in elimination of diazepam, phenytoin, and warfarin
  • Increased plasma concentrations of Opal and clarithromycin during concomitant administration

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment initiation if gastric ulcer is suspected

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, light headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Various other isolated reported effects

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child based on prospective studies
  • Use during pregnancy considered safe
  • No information on passage into breast milk or effects on the neonate
  • Discontinuation of breastfeeding if Omeprazole use is essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treated patients
  • Potential for methotrexate toxicities when used concomitantly

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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