Opra 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 4.50 (10 x 10: ৳ 450.00)
Strip Price: ৳ 45.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Cosmo pharma laboratories ltd |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell
- Onset of the antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- Benign gastric and duodenal ulcer: 20 mg once daily for 4-8 weeks
- NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 8 weeks
- Gastro-esophageal reflux disease: 20 mg once daily for 4-8 weeks, maintenance dose is 20 mg once daily
- Long-term management of acid reflux disease: 10-20 mg daily
- Acid-related dyspepsia: 10-20 mg once daily for 2-4 weeks
- Prophylaxis of acid aspiration: 40 mg on the preceding evening then 40 mg 2-6 hours before surgery
- Zollinger-Ellison syndrome: Initially 60 mg once daily, usual range 20-120 mg daily
- Helicobacter pylori eradication regimen in peptic ulcer disease: Omeprazole is recommended at a dose of 20 mg twice daily in association with antimicrobial agents
Administration
- Omeprazole lyophilized powder and water for injection is for intravenous administration only
- IV infusion should be given over a period of 20-30 minutes or more
- IV injection should be given slowly over a period of at least 2 to 5 minutes at a maximum rate of 4 ml/minute
- IV infusion solution should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose
- Reconstituted solution should not be mixed with any other drug in the same infusion set
Interaction
- Decreased intragastric acidity may reduce the absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin, and warfarin
- Concomitant treatment with certain drugs may result in increased plasma concentrations of Omeprazole and other medications
Contraindications
- Known hypersensitivity to Omeprazole
- Suspicion of gastric ulcer requires exclusion of malignancy before treatment initiation
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus reported
- Diarrhoea and headache may be severe in a small number of patients
- Gastrointestinal reactions including constipation, nausea/vomiting, flatulence, and abdominal pain
- Various isolated cases of adverse effects reported such as photosensitivity, bullous eruption, erythema multiforme, and alopecia
Pregnancy & Lactation
- No adverse effects of Omeprazole on pregnancy or the health of the fetus/newborn child reported
- Use during pregnancy can be considered safe based on prospective epidemiological studies
- No information available on the passage of Omeprazole into breast milk or its effects on the neonate
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Omeprazole
- Observational studies suggest a potential increased risk for osteoporosis-related fractures with PPI therapy
- Atrophic gastritis noted occasionally in patients treated long-term with Omeprazole
- Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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