Clit 80 mg/5 ml (Syrup)

Indications

• Treatment of malaria
• Prophylaxis and suppression of malaria
• Treatment of amoebic hepatitis and abscess
• Treatment of discoid and systemic lupus erythematosus
• Treatment of rheumatoid arthritis

Composition

• Tablet: Each film coated tablet contains Chloroquine Phosphate BP 250 mg equiv. to approx. 150 mg of Chloroquine base
• Syrup: Each 5 mL contains Chloroquine Phosphate BP 80 mg equiv. to approx. 50 mg of Chloroquine base

Pharmacology

• 4-aminoquinoline antimalarial and amoebicidal agent
• Used for the suppression and clinical cure of malaria
• Effective against susceptible strains of Plasmodium falciparum, P. ovale, P. vivax and P. malariae
• Rapidly acting blood schizontocide with gametocytocidal activity
• Mechanism of action may involve influencing haemoglobin digestion and synthesis of nucleoproteins by the parasite

Dosage & Administration

• Doses are normally expressed in terms of chloroquine base
• For the treatment of acute attack of malaria for adults and children
• For clinical prophylaxis in adults and children
• For hepatic amoebiasis in adults
• For discoid and systemic lupus erythematosus with suggested oral dose
• For rheumatoid arthritis in adults and children
• For the management of photoallergic reactions in adults and children
• For porphyria cutanea tarda in adults

Interaction

• Interacts with neostigmine, pyridostigmine, antacids, kaolin, cimetidine, ranitidine, quinine, mefloquine, amodiaquine, artemisinin, metronidazole, ampicillin

Contraindications

• Known or suspected chloroquine resistance in P. falciparum
• Hypersensitivity
• Retinal damage
• Concurrent therapy with hepatotoxic drugs

Side Effects

• Gastro-intestinal: Nausea, vomiting and diarrhoea
• Psychological: Psychotic episodes, anxiety and personality changes
• Visual disturbances: Blurred vision and difficulties in focusing, keratopathy, retinopathy
• Haematological: Aplastic anaemia, agranulocytosis, thrombocytopenia and neutropenia
• Others: Loss of hair, bleaching of hair pigment, photosensitivity, tinnitus, reduced hearing, nerve deafness, uromyopathy and myopathy

Pregnancy & Lactation

• Use of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria under physician's judgement
• Consideration needed for nursing infants from chloroquine

Precautions & Warnings

• Eyes should be examined before starting long-term treatment
• Visual disturbances may render patients unfit to take charge of vehicles or machinery
• Care is necessary in administering to patients with impaired liver or renal function, or with prophyria, psoriasis, or a history of epilepsy
• Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency should be observed for haemolytic anaemia during chloroquine treatment

Therapeutic Class

• Anti-malarial drugs

Storage Conditions

• Keep below 30°C temperature, away from light & moisture
• Keep out of the reach of children

Related Brands

• Malorin 80 mg/5 ml (Syrup) - albion-laboratories-limited