Ozole 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 4.50 (90's pack: ৳ 405.00)

Medicine Details

Category Details
Generic Omeprazole
Company Peoples pharma ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer
  • Long-term management of acid reflux disease

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • Oral administration
  • 20 mg once daily for duodenal ulceration
  • 8 weeks in gastric ulceration
  • 40 mg daily for severe or recurrent cases
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 20 mg for 4 weeks in gastro-esophageal reflux disease
  • 40 mg for 8 weeks in refractory cases of gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease

Administration

  • IV injection for prophylaxis of acid aspiration
  • IV infusion over 20-30 minutes
  • Intravenous administration only
  • Slow intravenous injection
  • Reconstitution with water for injection or saline for infusion
  • Use within specified time after reconstitution

Interaction

  • Decreased intragastric acidity affects ketoconazole absorption
  • Metabolized in liver through cytochrome P450
  • Can delay elimination of diazepam, phenytoin, and warfarin
  • Potential interactions with clarithromycin, digoxin, and other drugs

Contraindications

  • Hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Gastrointestinal reactions including constipation and nausea/vomiting
  • Dizziness, light headedness, and somnolence
  • Reversible mental confusion and myalgic symptoms
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child reported in studies
  • Use during pregnancy considered safe
  • No information on passage into breast milk or effects on neonate
  • Breastfeeding should be discontinued if essential use is considered
  • Safety and effectiveness not established in pediatric patients

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in long-term treated patients
  • Potential methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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