PPI 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 9.00 (4 x 10: ৳ 360.00)
Strip Price: ৳ 90.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Acme laboratories ltd |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell
- Onset of antisecretory effect within one hour
- Maximum effect occurring within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- Oral administration for various conditions
- Doses ranging from 10mg to 120mg depending on the condition
- Specific regimens for pediatric use
- Intravenous administration for prophylaxis of acid aspiration and other conditions
Administration
- Directions for use of IV Injection
- Directions for use of IV Infusion
- Preparation and reconstitution instructions
- IV administration guidelines
Interaction
- Potential interaction with ketoconazole affecting absorption
- Metabolism through cytochrome P450 affecting drugs like diazepam, phenytoin, and warfarin
- Monitoring and potential dose adjustment for concomitant use with warfarin or phenytoin
- Plasma concentration changes during concurrent administration
- No evidence of interaction with certain drugs and substances
Contraindications
- Known hypersensitivity to omeprazole
- Exclusion of malignancy before treatment
Side Effects
- Well-tolerated with generally mild and reversible adverse reactions
- Reports of skin reactions, gastrointestinal symptoms, and neurological effects
- Rare reports of hepatic and hematological adverse events
Pregnancy & Lactation
- Results from epidemiological studies indicating no adverse effects on pregnancy
- No information available on passage into breast milk and effects on neonate
- Recommendation to discontinue breastfeeding if essential
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Observational association with increased risk for osteoporosis-related fractures
- Potential development of atrophic gastritis with long-term use
- Potential interaction with methotrexate leading to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children
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