Dydroton 25 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Chlorthalidone |
| Company | Unimed unihealth pharmaceuticals ltd |
Indications
- Hypertension management
- Adjunctive therapy in edema associated with congestive heart failure
- Adjunctive therapy in edema associated with hepatic cirrhosis
- Adjunctive therapy in edema associated with corticosteroid therapy
- Adjunctive therapy in edema associated with estrogen therapy
Pharmacology
- Thiazide-type Diuretic-Antihypertensive
- Treatment of hypertension
- Adjunctive therapy of edema associated with renal disease
- Adjunctive therapy of edema associated with ascites due to cirrhosis of the liver
- Potassium loss promoting water loss
- Long elimination half-life
- Volume reduction effect on blood pressure
- Metabolism and hepatic excretion
Dosage & Administration
- Initiation with lowest possible dose
- Titration for maximum therapeutic benefit with minimum side effects
- Recommended dosing with food
- Usual adult dose of 25 to 50 mg daily for hypertension
- Lowest effective dose for edema
- Adjustment for elderly patients
Interaction
- Caution in hepatic function impairment
- Cautious usage in postsympathectomy patients
- Diuretic potentiation with antihypertensive agents
- Digitalis-induced cardiac arrhythmia potential
- Increased hypokalemic effects with corticosteroids
- Need for adjustment of insulin or oral antidiabetic agents
- Weakened diuretic activity with certain NSAIDs
- Increased responsiveness to curare derivatives and ganglionic blocking agents
- Potential hypersensitivity reaction increase with thiazide diuretics use
- Renal excretion reduction of cytotoxic agents with thiazide diuretics use
- Bioavailability increase with anticholinergic agents
- Decreased absorption by cholestyramine
- Urinary excretion decrease of calcium with thiazide diuretics use
- Increase in serum calcium with thiazide diuretics use
- Hyperglycemic effect enhancement by thiazide diuretics
Contraindications
- Anuria
- Severe renal failure
- Severe hepatic failure
- Refractory hypokalemia
- Enhanced potassium loss conditions
- Hyponatremia
- Hypercalcemia
- Symptomatic hyperuricemia
- Hypersensitivity to Chlorthalidone and other sulfonamide derivatives
- Caution in renal disease and impaired hepatic function
Side Effects
- Hypokalemia
- Hyperuricemia
- Rise in blood lipids
- Hyponatremia
- Hypomagnesemia
- Hyperglycemia
- Hypercalcemia
- Glycosuria
- Gout
- Hypochloremic alkalosis
- Urticaria and other forms of skin rash
- Photosensitization
- Intrahepatic cholestasis or jaundice
- Postural hypotension
- Cardiac arrhythmias
- Dizziness
- Slow mentation
- Decreased reaction time
Pregnancy & Lactation
- Avoiding use during pregnancy
- Avoiding use in lactating mothers
- Placental hypoperfusion potential
- Presence in breast milk
Precautions & Warnings
- Dosage adjustment in renal impairment
- Risk of hepatic encephalopathy in liver cirrhosis patients
- Avoidance in pregnancy and lactation
- Avoidance in lactating mothers due to lactation suppression
Overdose Effects
- Symptoms of acute overdosage
- Nausea
- Weakness
- Dizziness
- Disturbances of electrolyte balance
- No specific antidote
- Gastric lavage recommended
Therapeutic Class
- Thiazide diuretics & related drugs
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children