Prazole 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (5 x 14: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Omeprazole
Company Renata limited

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for 4 weeks in duodenal ulceration
  • 8 weeks in gastric ulceration
  • 40 mg daily in severe or recurrent cases
  • Maintenance dose for recurrent duodenal ulcer 20 mg once daily
  • 10-20 mg daily for prevention of relapse in duodenal ulcer
  • 40 mg once daily in severe ulcerating reflux esophagitis for 4-12 weeks
  • 10-20 mg once daily for acid-related dyspepsia for 2-4 weeks
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • 20 mg twice daily in H. pylori eradication regimen in peptic ulcer disease with antimicrobial agents for one week
  • 40 mg IV injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer or reflux oesophagitis
  • 60 mg IV injection for Zollinger-Ellison syndrome
  • 10-40 mg oral dose for severe ulcerating reflux esophagitis in pediatric patients weighing 10-40 kg
  • 10-20 mg daily for long-term management of acid reflux disease

Administration

  • Intravenous administration only
  • Slow intravenous injection over 2 to 5 minutes
  • Intravenous infusion over 20-30 minutes or more
  • Reconstituted solution should be used within 4 hours for injection and 12 hours for infusion
  • Solution should not be mixed or co-administered with any other drug

Interaction

  • Decreased intragastric acidity can reduce absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentrations increase during concomitant administration with clarithromycin
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, antacids, piroxicam, diclofenac, or naproxen
  • Simultaneous treatment with digoxin can increase the bioavailability of digoxin
  • Alcohol or food does not affect absorption

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer should exclude malignancy before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhea, headache, constipation, nausea, vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, light-headedness, and feeling faint
  • Somnolence, insomnia, and vertigo
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock
  • Malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, and hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • Considered safe for use during pregnancy
  • No information available on passage into breast milk or effects on the neonate
  • Discontinue breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • PPI therapy may be associated with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in patients treated long-term
  • Concomitant use with methotrexate may lead to methotrexate toxicities
  • Safety and effectiveness not established in pediatric patients under 18 years of age

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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