Prazole 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 5.00 (5 x 14: ৳ 350.00)
Strip Price: ৳ 70.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Renata limited |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of the antisecretory effect occurs within one hour
- Maximum effect occurs within two hours
- Inhibition of secretion lasts up to 72 hours
- Secretory activity returns gradually over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for 4 weeks in duodenal ulceration
- 8 weeks in gastric ulceration
- 40 mg daily in severe or recurrent cases
- Maintenance dose for recurrent duodenal ulcer 20 mg once daily
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 40 mg once daily in severe ulcerating reflux esophagitis for 4-12 weeks
- 10-20 mg once daily for acid-related dyspepsia for 2-4 weeks
- 40 mg on the preceding evening for prophylaxis of acid aspiration
- 20 mg twice daily in H. pylori eradication regimen in peptic ulcer disease with antimicrobial agents for one week
- 40 mg IV injection for prophylaxis of acid aspiration, duodenal ulcer, gastric ulcer or reflux oesophagitis
- 60 mg IV injection for Zollinger-Ellison syndrome
- 10-40 mg oral dose for severe ulcerating reflux esophagitis in pediatric patients weighing 10-40 kg
- 10-20 mg daily for long-term management of acid reflux disease
Administration
- Intravenous administration only
- Slow intravenous injection over 2 to 5 minutes
- Intravenous infusion over 20-30 minutes or more
- Reconstituted solution should be used within 4 hours for injection and 12 hours for infusion
- Solution should not be mixed or co-administered with any other drug
Interaction
- Decreased intragastric acidity can reduce absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin, and warfarin
- Plasma concentrations increase during concomitant administration with clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxicillin, antacids, piroxicam, diclofenac, or naproxen
- Simultaneous treatment with digoxin can increase the bioavailability of digoxin
- Alcohol or food does not affect absorption
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer should exclude malignancy before treatment
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, and erythema multiforme
- Diarrhea, headache, constipation, nausea, vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, light-headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema, increased sweating, gynaecomastia, leucopenia, thrombocytopenia, agranulocytosis, pancytopenia, anaphylactic shock
- Malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, and hepatic failure
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or on the health of the fetus/newborn child
- Considered safe for use during pregnancy
- No information available on passage into breast milk or effects on the neonate
- Discontinue breastfeeding if essential
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- PPI therapy may be associated with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in patients treated long-term
- Concomitant use with methotrexate may lead to methotrexate toxicities
- Safety and effectiveness not established in pediatric patients under 18 years of age
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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