Prevas 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | General pharmaceuticals ltd |
Also available as |
Indications
- Treatment of gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximium effect within two hours
- Inhibition of secretion lasts up to 72 hours
- Gradual return of secretory activity over 3 to 5 days after discontinuation
Dosage
- 20 mg once daily for benign gastric and duodenal ulcer
- 40 mg daily for severe or recurrent cases
- 10-20 mg daily for prevention of relapse in duodenal ulcer
- 20 mg once daily for NSAID-associated duodenal or gastric ulcer
- 20 mg once daily for 4-8 weeks for gastro-esophageal reflux disease
- 40 mg once daily for 8 weeks in refractory gastro-esophageal reflux disease
- 10-20 mg daily for long-term management of acid reflux disease
- 10-20 mg once daily for 2-4 weeks for acid-related dyspepsia
- 40 mg for prophylaxis of acid aspiration during general anesthesia
- 60 mg once daily for Zollinger-Ellison syndrome
- Amoxicillin 500 mg and Metronidazole 400 mg both three times a day for one week for Helicobacter pylori-induced peptic ulcer
- Clarithromycin 250 mg and Metronidazole 400 mg both twice a day for one week for Helicobacter pylori-induced peptic ulcer
Administration
- For intravenous administration only
- IV injection given slowly over a period of 5 minutes
- IV infusion given over a period of 20-30 minutes or more
- Solution for IV injection to be used within 4 hours of reconstitution
- Solution for IV infusion to be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose
Interaction
- Decreased intragastric acidity may reduce absorption of ketoconazole
- Metabolised in the liver through cytochrome P450, may delay the elimination of diazepam, phenytoin, and warfarin
- May increase plasma concentrations of clarithromycin
- No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, or antacids
- Absorption not affected by alcohol or food
- No evidence of interaction with piroxicam, diclofenac, or naproxen
- May increase the bioavailability of digoxin
- Monitoring and dose adjustment recommended for warfarin or phenytoin when given concomitantly
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer should exclude the possibility of malignancy before treatment
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
- Diarrhoea and headache
- Constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia, dizziness, light-headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral oedema, increased sweating, gynaecomastia, and hematologic disorders
- Anaphylactic shock, malaise, fever, bronchospasm, encephalopathy, hepatitis, interstitial nephritis, and hepatic failure
Pregnancy & Lactation
- No adverse effects on pregnancy or health of fetus/newborn child in epidemiological studies
- Use during pregnancy considered safe
- No information on passage into breast milk or effects on the neonate
- Breastfeeding should be discontinued if essential
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- PPI therapy may be associated with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in gastric corpus biopsies from long-term treatment
- Concomitant use with methotrexate may lead to methotrexate toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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