Epram 10 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)

Strip Price: ৳ 100.00

Medicine Details

Category	Details
Generic	Escitalopram oxalate
Company	Albion laboratories limited
Also available as	Epram 5 mg tablet

Selective serotonin reuptake inhibitor (SSRI)
Pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram
100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
Low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors

Safe daily doses below 20 mg
Single daily dose, may be taken with or without food
Usual dosage for major depressive episodes is 10 mg once daily, can be increased to a maximum of 20 mg daily
Initial dose of 5 mg recommended for panic disorder with or without agoraphobia
Usual dosage for social anxiety disorder is 10 mg once daily, dose may be increased to a maximum of 20 mg daily
Initial dosage for generalised anxiety disorder is 10 mg once daily, may be increased to a maximum of 20 mg daily
Initial dosage for obsessive-compulsive disorder is 10 mg once daily, may be increased to a maximum of 20 mg daily

SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
Conversely, an MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped

Contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated

Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
Side-effects include gastrointestinal effects, anorexia with weight loss, hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, asthenia, hallucinations, drowsiness, convulsions, galactorrhoea, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders and dyskinesias, visual disturbances

Consider potential risks and benefits of treatment when treating a pregnant woman with Escitalopram during the third trimester
Excreted in human breast milk
Decision whether to continue or discontinue nursing or Escitalopram therapy should take into account the risk of citalopram exposure for the infant and the benefits of Escitalopram treatment for the mother

Use with caution in patients with epilepsy, concurrent electroconvulsive therapy, history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase risk of bleeding, history of bleeding disorders, hepatic and renal impairment

Elderly patients (>65 years of age) - Initial dosage is 5 mg once daily, may be increased to 10 mg daily
Children and adolescents (<18 years) - Not recommended for use
Reduced renal function - Dosage adjustment may be necessary in severely reduced renal function
Reduced hepatic function - An initial dose of 5 mg daily for the first two weeks of treatment is recommended in patients with mild or moderate hepatic impairment
Poor metabolizers of CYP2C19 - Initial dose of 5 mg daily recommended, gradual reduction of dose upon discontinuation of treatment

Symptoms of overdose include dizziness, tremor, agitation, serotonin syndrome, convulsion, coma, nausea/vomiting, hypotension, tachycardia, QT interval prolongation, arrhythmia, electrolyte/fluid balance conditions
No specific antidote, general symptomatic supportive measures recommended