Andepram 10 mg (Tablet)

Unit Price: ৳ 13.00 (2 x 14: ৳ 364.00)
Strip Price: ৳ 182.00

Medicine Details

Category Details
Generic Escitalopram oxalate
Company Radiant pharmaceuticals ltd
Also available as

Indications

  • Treatment of major depressive episodes
  • Treatment of panic disorder with or without agoraphobia
  • Treatment of social anxiety disorder (social phobia)
  • Treatment of generalised anxiety disorder
  • Treatment of obsessive-compulsive disorder

Pharmacology

  • Escitalopram is an orally administered selective serotonin reuptake inhibitor (SSRI)
  • Escitalopram is the pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram
  • At least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
  • No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors

Dosage

  • Safety of daily doses above 20 mg has not been demonstrated
  • Usual dosage for major depressive episodes is 10 mg once daily, with a maximum of 20 mg daily
  • Initial dose of 5 mg is recommended for panic disorder before increasing to 10 mg daily, with a maximum of 20 mg daily
  • Usual dosage for social anxiety disorder is 10 mg once daily, with a maximum of 20 mg daily
  • Initial dosage for obsessive-compulsive disorder is 10 mg once daily, with a maximum of 20 mg daily

Administration

  • Escitalopram should generally be administered once daily, morning or evening with or without food

Interaction

  • SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
  • An MAOI should not be started until at least a week after an SSRI has been stopped

Contraindications

  • Escitalopram is contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram
  • Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated

Side Effects

  • Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
  • Side-effects include gastrointestinal effects, anorexia with weight loss or increased appetite and weight gain, hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, and more

Pregnancy & Lactation

  • Physician should carefully consider the potential risks and benefits of treatment in pregnant women during the third trimester
  • Excreted in human breast milk

Precautions & Warnings

  • SSRIs should be used with caution in patients with epilepsy, cardiac disease, diabetes mellitus, angle-closure glaucoma, and more
  • Dosage adjustment is not necessary in patients with mild or moderate renal impairment

Use in Special Populations

  • Initial dosage for elderly patients (>65 years of age) is 5 mg once daily
  • Use is not recommended for children and adolescents (<18 years)
  • No dosage adjustment is necessary in patients with mild or moderate renal impairment

Overdose Effects

  • Symptoms include mainly related to the central nervous system, gastrointestinal system, cardiovascular system, and electrolyte/fluid balance conditions
  • No specific antidote, general symptomatic supportive measures are recommended

Therapeutic Class

  • SSRIs & related anti-depressant drugs

Storage Conditions

  • Store below 30°C temperature and protect from light & moisture
  • Keep the medicine out of the reach of children

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