Andepram 10 mg (Tablet)
Unit Price: ৳ 13.00 (2 x 14: ৳ 364.00)
Strip Price: ৳ 182.00
Medicine Details
Category | Details |
---|---|
Generic | Escitalopram oxalate |
Company | Radiant pharmaceuticals ltd |
Also available as |
Indications
- Treatment of major depressive episodes
- Treatment of panic disorder with or without agoraphobia
- Treatment of social anxiety disorder (social phobia)
- Treatment of generalised anxiety disorder
- Treatment of obsessive-compulsive disorder
Pharmacology
- Escitalopram is an orally administered selective serotonin reuptake inhibitor (SSRI)
- Escitalopram is the pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram
- At least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
- No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors
Dosage
- Safety of daily doses above 20 mg has not been demonstrated
- Usual dosage for major depressive episodes is 10 mg once daily, with a maximum of 20 mg daily
- Initial dose of 5 mg is recommended for panic disorder before increasing to 10 mg daily, with a maximum of 20 mg daily
- Usual dosage for social anxiety disorder is 10 mg once daily, with a maximum of 20 mg daily
- Initial dosage for obsessive-compulsive disorder is 10 mg once daily, with a maximum of 20 mg daily
Administration
- Escitalopram should generally be administered once daily, morning or evening with or without food
Interaction
- SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
- An MAOI should not be started until at least a week after an SSRI has been stopped
Contraindications
- Escitalopram is contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram
- Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated
Side Effects
- Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
- Side-effects include gastrointestinal effects, anorexia with weight loss or increased appetite and weight gain, hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, and more
Pregnancy & Lactation
- Physician should carefully consider the potential risks and benefits of treatment in pregnant women during the third trimester
- Excreted in human breast milk
Precautions & Warnings
- SSRIs should be used with caution in patients with epilepsy, cardiac disease, diabetes mellitus, angle-closure glaucoma, and more
- Dosage adjustment is not necessary in patients with mild or moderate renal impairment
Use in Special Populations
- Initial dosage for elderly patients (>65 years of age) is 5 mg once daily
- Use is not recommended for children and adolescents (<18 years)
- No dosage adjustment is necessary in patients with mild or moderate renal impairment
Overdose Effects
- Symptoms include mainly related to the central nervous system, gastrointestinal system, cardiovascular system, and electrolyte/fluid balance conditions
- No specific antidote, general symptomatic supportive measures are recommended
Therapeutic Class
- SSRIs & related anti-depressant drugs
Storage Conditions
- Store below 30°C temperature and protect from light & moisture
- Keep the medicine out of the reach of children