Clarith 500 mg (Tablet)

Unit Price: ৳ 30.00 (1 x 10: ৳ 300.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Clarithromycin
Company Ibn sina pharmaceuticals ltd
Also available as
Clarith 125 mg suspension

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibits microsomal protein synthesis
  • Binds to the donor site on the 50S subunit of the bacterial ribosome
  • Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
  • More acid-stable than Erythromycin
  • Twice the activity of Erythromycin against H. influenzae

Dosage & Administration

  • Multiple dosage regimens for different conditions
  • Dosing for adults and pediatric patients
  • Special dosing for H. pylori infection
  • Dosage adjustment for renal and hepatic impairment

Interaction

  • Contraindicated with specific medications such as HMG-CoA reductase inhibitors and gastroprokinetic agents
  • Not recommended with antiarrhythmics drugs

Contraindications

  • Known hypersensitivity to clarithromycin, erythromycin, or macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Stomatitis
  • Glossitis
  • Headache
  • Allergic reactions
  • Taste perversion
  • Transient central nervous system side effects

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Caution advised for breastfeeding mothers

Precautions & Warnings

  • Discontinue if severe acute hypersensitivity reactions occur
  • Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
  • Increased risk of all-cause mortality in patients with coronary artery disease

Use in Special Populations

  • Safety and effectiveness in pediatric patients established for certain conditions
  • Safety not established in pediatric patients under 6 months of age

Overdose Effects

  • Ingestion of large amounts can produce gastro-intestinal symptoms

Therapeutic Class

  • Macrolides

Storage Conditions

  • Store in a cool and dry place, protected from light & moisture
  • Reconstituted suspension must be used within specific timeframes

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