Probitor 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 7.10 (10 x 10: ৳ 710.00)
Strip Price: ৳ 71.00
Medicine Details
Category | Details |
---|---|
Generic | Omeprazole |
Company | Sandoz a novartis division |
Also available as |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocker of hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- Benign gastric and duodenal ulcer: 20 mg once daily for 4 weeks
- NSAID-associated duodenal or gastric ulcer: 20 mg once daily for 4 weeks
- Gastro-esophageal reflux disease: 20 mg once daily for 4 weeks
- Long-term management of acid reflux disease: 10-20 mg daily
- Prophylaxis of acid aspiration: 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery
- Zollinger-Ellison syndrome: Initially 60 mg once daily
- Paediatric use in severe ulcerating reflux esophagitis: If body-weight 10-20 kg, 10-20 mg once daily for 4-12 weeks
Administration
- For intravenous administration only
- IV Injection: Given slowly over a period of 5 minutes
- IV Infusion: Given over a period of 20-30 minutes or more
Interaction
- Decreased intragastric acidity affecting the absorption of ketoconazole
- Metabolized in the liver through cytochrome P450
- Can delay the elimination of diazepam, phenytoin and warfarin
- Plasma concentrations increased during concomitant administration with other drugs
Contraindications
- Known hypersensitivity to omeprazole
- Suspicion of gastric ulcer with possibility of malignancy
Side Effects
- Skin rash, urticaria, pruritus
- Photosensitivity, bullous eruption, erythema multiforme
- Diarrhoea, headache, constipation
- Nausea/vomiting, flatulence, abdominal pain
- Dry mouth, stomatitis, candidiasis
- Paraesthesia, dizziness, light headedness
- Somnolence, insomnia, vertigo
- Mental confusion, agitation, depression
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral oedema
- Increased sweating, gynaecomastia, leucopenia
- Thrombocytopenia, agranulocytosis, pancytopenia
- Anaphylactic shock, malaise, fever
- Bronchospasm, encephalopathy, hepatitis
- Increases in liver enzymes
Pregnancy & Lactation
- No adverse effects on pregnancy or fetus/newborn child
- Use during pregnancy is acceptable
- No information on passage into breast milk or effects on the neonate
- Breast-feeding should be discontinued if essential
Precautions & Warnings
- Avoid concomitant use with clopidogrel
- Increased risk for osteoporosis-related fractures
- Atrophic gastritis noted in long-term treatment
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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