Remac 125 mg/5 ml (Powder for Suspension)
60 ml bottle: ৳ 395.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Prevention of translocation at the donor site
- Activity against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
- Twice the activity of Erythromycin against H. influenzae
- More acid-stable than Erythromycin
- Resistance of most species of Gram-negative bacteria to Clarithromycin
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis in adults
- Dosage for community-acquired pneumonia in adults
- Dosage for pharyngitis or tonsillitis in adults
- Dosage for uncomplicated skin and skin structure infections in adults
- Dosage for treatment and prophylaxis of disseminated Mycobacterium avium disease in adults
- Triple therapy dosing regimen for H. pylori infection
- Dosage for pediatric patients
- Dosage adjustment for renal and hepatic impairment
Interaction
- Contraindication with HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, and anti-gout agents
- Not recommended to use with antiarrhythmics drugs
Contraindications
- Hypersensitivity to clarithromycin, erythromycin, or any macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Use in neonates and children
- Avoidance of breastfeeding while receiving Clarithromycin
Precautions & Warnings
- Discontinuation in case of severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Discontinuation in case of signs and symptoms of hepatitis
- Increased risk of all-cause mortality in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Use in children and adolescents for specific indications
Overdose Effects
- Gastrointestinal symptoms with ingestion of large amounts
- Altered mental status
- Paranoid behavior
- Adverse reactions treatment and supportive measures
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry place for storage
- Protection from light and moisture
- Limited shelf life of reconstituted suspension