Klavin 500 mg (Tablet)
Unit Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Virgo pharmaceuticals ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
- More acid-stable than Erythromycin
- Twice the activity of Erythromycin against H. influenzae
- Resistance in most species of Gram-negative bacteria
Dosage & Administration
- Specific dosages for different indications in adults
- Combination dosing regimens for H. pylori infection
- Recommended daily dosages for children
- Administration in renal and hepatic impairment
Drug Interaction
- Contraindicated with specific medications like HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics
Contraindications
- Known hypersensitivity to clarithromycin, erythromycin, or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea, vomiting, diarrhea, and abdominal pain
- Stomatitis and glossitis
- Headache, allergic reactions, taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Appropriate use in neonates and children
- Avoiding breast milk from mothers receiving Clarithromycin
- Not recommended for pregnant patients
Precautions & Warnings
- Discontinuation in case of severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation or receiving specific drugs
- Discontinuation in case of hepatitis signs and symptoms
- Risk in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in children and adolescents
- Established treatments for specific pediatric patients
Overdose Effects
- Gastro-intestinal symptoms with large amounts
- Altered mental status and paranoid behavior reported in one case of overdose
- Prompt elimination of unabsorbed drug and supportive measures for adverse reactions
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry place, protected from light & moisture
- Reconstituted suspension expiry details
- Keep out of reach of children