Klavin 500 mg (Tablet)

Unit Price: ৳ 40.00

Medicine Details

Category Details
Generic Clarithromycin
Company Virgo pharmaceuticals ltd
Also available as
Klavin 125 mg suspension

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibits microsomal protein synthesis in susceptible organisms
  • Binds to the donor site on the 50S subunit of the bacterial ribosome
  • Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
  • More acid-stable than Erythromycin
  • Twice the activity of Erythromycin against H. influenzae
  • Resistance in most species of Gram-negative bacteria

Dosage & Administration

  • Specific dosages for different indications in adults
  • Combination dosing regimens for H. pylori infection
  • Recommended daily dosages for children
  • Administration in renal and hepatic impairment

Drug Interaction

  • Contraindicated with specific medications like HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics

Contraindications

  • Known hypersensitivity to clarithromycin, erythromycin, or macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

  • Nausea, vomiting, diarrhea, and abdominal pain
  • Stomatitis and glossitis
  • Headache, allergic reactions, taste perversion
  • Transient central nervous system side effects

Pregnancy & Lactation

  • Appropriate use in neonates and children
  • Avoiding breast milk from mothers receiving Clarithromycin
  • Not recommended for pregnant patients

Precautions & Warnings

  • Discontinuation in case of severe acute hypersensitivity reactions
  • Avoidance in patients with known QT prolongation or receiving specific drugs
  • Discontinuation in case of hepatitis signs and symptoms
  • Risk in patients with coronary artery disease

Use in Special Populations

  • Safety and effectiveness in children and adolescents
  • Established treatments for specific pediatric patients

Overdose Effects

  • Gastro-intestinal symptoms with large amounts
  • Altered mental status and paranoid behavior reported in one case of overdose
  • Prompt elimination of unabsorbed drug and supportive measures for adverse reactions

Therapeutic Class

  • Macrolides

Storage Conditions

  • Cool and dry place, protected from light & moisture
  • Reconstituted suspension expiry details
  • Keep out of reach of children

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