Klavin 125 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 300.00

Medicine Details

Category Details
Generic Clarithromycin
Company Virgo pharmaceuticals ltd
Also available as
Klavin 500 mg tablet

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibition of microsomal protein synthesis in susceptible organisms
  • Binding to the donor site on the 50S subunit of the bacterial ribosome
  • Activity against most Gram-positive bacteria and Chlamydia, some Gram-negative bacteria and Mycoplasmas
  • Acid-stable and better tolerated compared to Erythromycin
  • Twice the activity of Erythromycin against H. influenzae
  • Most species of Gram-negative bacteria are resistant to Clarithromycin

Dosage & Administration

  • Dosage varies based on condition and patient group
  • Combination dosing regimens for H. pylori infection
  • Recommended dosages for adults and children
  • Adjustment in patients with renal and hepatic impairment

Interaction

  • Contraindicated with specific medications such as HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and antiarrhythmics
  • Caution required with certain drug interactions

Contraindications

  • Known hypersensitivity to clarithromycin, erythromycin, or any macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

  • Nausea, vomiting, diarrhea, and abdominal pain
  • Stomatitis and glossitis
  • Headache, allergic reactions, taste perversion
  • Transient central nervous system side effects including anxiety, dizziness, insomnia, and hallucination

Pregnancy & Lactation

  • Use in neonates and children in appropriate doses
  • Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed

Precautions & Warnings

  • Discontinue if severe acute hypersensitivity reactions occur
  • Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
  • Discontinue if signs and symptoms of hepatitis occur
  • Increased risk of all-cause mortality in patients with coronary artery disease post-treatment
  • Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs

Use in Special Populations

  • Safety and effectiveness established for various conditions in pediatric patients
  • Limited safety data for children under 6 months of age

Overdose Effects

  • Ingestion of large amounts can produce gastro-intestinal symptoms
  • Altered mental status, paranoid behavior, hypokalemia, and hypoxemia observed in extreme overdose case
  • Prompt elimination of unabsorbed drug and supportive measures recommended for overdose reactions

Therapeutic Class

  • Macrolides

Storage Conditions

  • Store in a cool and dry place, protected from light & moisture
  • Reconstituted suspension must be used within specified timeframes
  • Keep out of reach of children

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