Danium 10 mg (Tablet)
Unit Price: ৳ 2.90 (100's pack: ৳ 290.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobazam |
| Company | Doctors chemical works ltd |
Indications
- Anxiety treatment
- Excitement relief
- Sleep disturbances from emotional causes
- Psychovegetative disorders
- Psychosomatic disorders
- Emotional instability relief
Pharmacology
- Binds to GABA receptor
- Increases chloride ionopore opening duration
- Hyperpolarization
- Stabilizes membrane
- Enhances post-synaptic inhibitory effect
Dosage
- Adjusted to indication severity and response
- Keep dose as low as possible
- Initial dose for adults and adolescents
- Maintenance dose for elderly
- Duration and timing of doses
- Secondary dosage adjustment
- Treatment duration
- Discontinuation guidelines
- Initial dose for epilepsy treatment
- Maintenance dose for children with epilepsy
- Dosing for elderly with epilepsy
Administration
- Whole or crushed tablet administration
- Can be mixed in applesauce
- Can be taken with or without food
Interaction
- Alcohol interaction
- Central nervous system depressant drugs interaction
- Opioids interaction
- Anticonvulsants interaction
- Narcotic analgesics interaction
- Muscle relaxants interaction
- CYP 2C19 inhibitors interaction
- CYP 2D6 substrates interaction
Contraindications
- Hypersensitivity to clobazam
- Myasthenia gravis
- Severe respiratory insufciency
- Sleep apnoea syndrome
- Severe impairment of liver function
- Breastfeeding
- Children between 6 months and 3 years
Side Effects
- Decreased appetite
- Irritability
- Aggression
- Restlessness
- Depression
- Sedation
- Dizziness
- Disturbance in attention
- Respiratory depression
- Dry mouth
- Nausea
- Constipation
- Rash
- Muscle spasms
- Fatigue
Pregnancy & Lactation
- Clobazam use in pregnancy
- Potential risks to fetus
- Transmission through breast milk
Precautions & Warnings
- Serious skin reactions monitoring
- Respiratory depression monitoring
- Muscle weakness monitoring
- Renal and hepatic impairment monitoring
- Elderly patient considerations
- Tolerance in epilepsy
- CYP2C19 poor metabolizers guidance
- Suicidality risks
- CYP2C19 inhibitors interaction guidance
Therapeutic Class
- Benzodiazepine hypnotics
Storage Conditions
- Do not use after expiry date
- Store below 30°C
- Protect from light
- Keep out of the reach of children